{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:13:54Z","timestamp":1745554434495,"version":"3.40.4"},"reference-count":6,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>The purpose of the present study was to clarify whether atypical \u03b2-adrenoceptors which presented in the guinea pig gastric fundus are \u03b2&lt;sub&gt;3&lt;\/sub&gt;-adrenoceptors or putative \u03b2&lt;sub&gt;4&lt;\/sub&gt;-adrenoceptors. In the presence of both the selective \u03b2&lt;sub&gt;1&lt;\/sub&gt;-adrenoceptor antagonist atenolol (10&lt;sup&gt;\u20134&lt;\/sup&gt; mol\/l) and the selective \u03b2&lt;sub&gt;2&lt;\/sub&gt;-adrenoceptor antagonist butoxamine (10&lt;sup&gt;\u20134&lt;\/sup&gt;\u00a0mol\/l), the selective \u03b2&lt;sub&gt;3&lt;\/sub&gt;-adrenoceptor antagonist SR59230A caused a concentration-dependent rightward shift of the concentration-response curve to catecholamines (isoprenaline, noradrenaline and adrenaline) and \u03b2&lt;sub&gt;3&lt;\/sub&gt;-adrenoceptor agonists (BRL37344 and CGP12177A) in the guinea pig gastric fundus. Schild plot analyses of SR59230A against these agonists gave pA&lt;sub&gt;2&lt;\/sub&gt; values of 7.35 \u00b1 0.03 (isoprenaline), 7.26 \u00b1 0.04 (noradrenaline), 7.26 \u00b1 0.05 (adrenaline), 7.79 \u00b1 0.03 (BRL37344) and 6.74 \u00b1 0.03 (CGP12177A), respectively, and all Schild slopes were not significantly different from unity. These results suggest that atypical \u03b2-adrenoceptors mediating relaxant responses of these agonists in the guinea pig gastric fundus are \u03b2&lt;sub&gt;3&lt;\/sub&gt;-adrenoceptors rather than putative \u03b2&lt;sub&gt;4&lt;\/sub&gt;-adrenoceptors.<\/jats:p>","DOI":"10.1159\/000056078","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:20Z","timestamp":1050433580000},"page":"98-102","source":"Crossref","is-referenced-by-count":7,"title":["Effect of SR59230A on Atypical \u03b2-Adrenoceptor Mediating Relaxation in the Guinea Pig Gastric Fundus"],"prefix":"10.1159","volume":"62","author":[{"given":"Takahiro","family":"Horinouchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuo","family":"Koike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,2,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0898-6568(94)90085-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000028332"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(79)90505-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(96)01024-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(96)01024-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(97)89942-7"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/56078","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/56078","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:44:38Z","timestamp":1745469878000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000056078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":6,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2001,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000056078","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"type":"print","value":"0031-7012"},{"type":"electronic","value":"1423-0313"}],"subject":[],"published":{"date-parts":[[2001]]}}}