{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:13:55Z","timestamp":1745554435434,"version":"3.40.4"},"reference-count":7,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2001]]},"abstract":"<jats:p>(\u00b1)-Pindolol ([1-(1H-indol-4-yloxy)-3-[(1-methylethyl)- amino]-2-propanol)]) is a partial agonist at atypical \u03b2-adrenoceptors in the guinea pig gastric fundus. (\u00b1)-Pindolol induced concentration-dependent relaxation in this tissue. However, the relaxant responses of (\u00b1)-pindolol were not antagonized by a combination of the selective \u03b2&lt;sub&gt;1&lt;\/sub&gt;-adrenoceptor antagonist atenolol (10&lt;sup&gt;\u20134&lt;\/sup&gt; mol\/l) and the selective \u03b2&lt;sub&gt;2&lt;\/sub&gt;-adrenoceptor antagonist butoxamine (10&lt;sup&gt;\u20134&lt;\/sup&gt; mol\/l). In the presence of both atenolol and butoxamine, the nonselective \u03b2&lt;sub&gt;1&lt;\/sub&gt;-, \u03b2&lt;sub&gt;2&lt;\/sub&gt;- and \u03b2&lt;sub&gt;3&lt;\/sub&gt;-adrenoceptor antagonist (\u00b1)-bupranolol (10&lt;sup&gt;\u20135&lt;\/sup&gt;\u201310&lt;sup&gt;\u20134&lt;\/sup&gt; mol\/l) caused a concentration-dependent rightward shift of the concentration-response curves for (\u00b1)-pindolol. Schild plot analyses of (\u00b1)-bupranolol against (\u00b1)-pindolol gave the pA&lt;sub&gt;2&lt;\/sub&gt; value of 5.46 \u00b1 0.03 and Schild slope was not significantly different from unity. Furthermore, (\u00b1)-pindolol (10&lt;sup&gt;\u20135&lt;\/sup&gt;\u00a0mol\/l) weakly but significantly antagonized the relaxant responses to catecholamines ((\u2013)-isoprenaline, (\u2013)-noradrenaline and (\u2013)-adrenaline), a selective \u03b2&lt;sub&gt;3&lt;\/sub&gt;-adrenoceptor agonist BRL37344 ((R*,R*)-(\u00b1)-4-[2-[(2-(3-chlorophenyl)-2-hydroxyethyl)amino]propyl]phenoxyacetic acid sodium salt) and a nonconventional partial \u03b2&lt;sub&gt;3&lt;\/sub&gt;-adrenoceptor agonist (\u00b1)-CGP12177A ([4-[3-[(1,1-dimethylethyl)amino]-2-hydroxypropoxy]-1,3-dihydro-2H-benzimidazol-2-one] hydrochloride). These results suggest that (\u00b1)-pindolol acts as a partial agonist at atypical \u03b2-adrenoceptors in the guinea pig gastric fundus.<\/jats:p>","DOI":"10.1159\/000056134","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:20Z","timestamp":1050433580000},"page":"197-202","source":"Crossref","is-referenced-by-count":0,"title":["Partial Agonistic Properties of (\u00b1)-Pindolol at Atypical \u03b2-Adrenoceptors in the Guinea Pig Gastric Fundus"],"prefix":"10.1159","volume":"63","author":[{"given":"Takahiro","family":"Horinouchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuo","family":"Koike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2001,12,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000028332"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(79)90505-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0165-6147(86)90377-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(96)01024-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(97)89942-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(96)01024-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(91)90492-9"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/56134","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/56134","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:45:08Z","timestamp":1745469908000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000056134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":7,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2001,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000056134","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"type":"print","value":"0031-7012"},{"type":"electronic","value":"1423-0313"}],"subject":[],"published":{"date-parts":[[2001]]}}}