{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T04:28:46Z","timestamp":1781065726511,"version":"3.54.1"},"reference-count":1,"publisher":"S. Karger AG","issue":"1-4","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Genome Res"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>It has previously been reported that 19% of the daughters of males carrying the X-linked mutation &lt;i&gt;patchy fur&lt;\/i&gt; (&lt;i&gt;Paf&lt;\/i&gt;) are XO with a maternally derived X chromosome. We now report that hemizygous &lt;i&gt;Paf &lt;\/i&gt;males that also carry the variant Y chromosome Y*, show a much increased XO production (\u223c40% of daughters). We hypothesize that the &lt;i&gt;Paf &lt;\/i&gt;mutation is associated with an inversion spanning the pseudoautosomal region (PAR) boundary, and that this leads to preferential crossing over between the resulting inverted region of PAR and an equivalent inverted PAR region within the compound Y* PAR. This would lead to the production of dicentric X and acentric Y products and consequent sex chromosome loss. This interpretation is supported by analysis of the sex chromosome complements at the second meiotic metaphase, which revealed a high incidence of dicentrics. Another curious feature of the &lt;i&gt;Paf &lt;\/i&gt;mutation is that mice that are homozygous &lt;i&gt;Paf&lt;\/i&gt; have more hair than mice that are hemizygous &lt;i&gt;Paf&lt;\/i&gt;. This can be explained if the &lt;i&gt;Paf&lt;\/i&gt; mutation is a hypomorphic mutation that escapes X inactivation because, unlike the wild type allele, it is now located within the PAR. \u00a0\u00a0\u00a0<\/jats:p>","DOI":"10.1159\/000056819","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:15Z","timestamp":1050433575000},"page":"57-61","source":"Crossref","is-referenced-by-count":37,"title":["A high frequency of XO offspring from X&lt;i&gt;&lt;sup&gt;Paf&lt;\/sup&gt;&lt;\/i&gt;Y* male mice: evidence that the &lt;i&gt;Paf&lt;\/i&gt; mutation involves an inversion spanning the X PAR boundary"],"prefix":"10.1159","volume":"91","author":[{"given":"P.S.","family":"Burgoyne","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.P.","family":"Evans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2001,1,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000014954"}],"container-title":["Cytogenetic and Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/56819","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/56819","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:51:58Z","timestamp":1745470318000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000056819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":1,"journal-issue":{"issue":"1-4","published-online":{"date-parts":[[2000,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000056819","archive":["Portico"],"relation":{},"ISSN":["1424-8581","1424-859X"],"issn-type":[{"value":"1424-8581","type":"print"},{"value":"1424-859X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000]]}}}