{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:14:32Z","timestamp":1745554472660,"version":"3.40.4"},"reference-count":2,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mineral Electrolyte Metab"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>Renal reserve was explored by means of an oral protein load (2 g\/kg body weight) under the form of cooked red meat in a group of 9 patients with end-stage heart failure (ESHF), class III of the New York Heart Association receiving loop diuretics and angiotensin-converting enzyme (ACE) inhibitors, and in a group of 18 healthy controls (HC) matched for age, gender, and height under an identical dietary regimen providing 40 cal\/kg per day, 1 g\/kg body weight of protein per day, Na 120 mmol\/day, and K 50 mmol\/day. Baseline glomerular filtration rate averaged 109.5\u00b19.89 ml\/min\u00d71.73 m&lt;sup&gt;2&lt;\/sup&gt; in HC and 71.9\u00b18.8 ml\/min\u00d71.73 m&lt;sup&gt;2&lt;\/sup&gt; in ESHF. Renal plasma flow averaged 540\u00b127 ml\/min\u00d71.73 m&lt;sup&gt;2&lt;\/sup&gt; in HC and 235\u00b147 ml\/min\u00d71.73 m&lt;sup&gt;2&lt;\/sup&gt; in ESHF. The filtration fraction was significantly higher in ESHF (p&lt;0.01). Renal reserve averaged 26.03\u00b13.28 ml\/min\u00d71.73 m&lt;sup&gt;2&lt;\/sup&gt; in HC and 27.2\u00b17.12 ml\/min\u00d71.73 m&lt;sup&gt;2&lt;\/sup&gt; (not significant). Renal reserve averaged 123.9\u00b12.9% in HC and 137.3\u00b16.68% in ESHF (not significant). The filtration capacity was significantly higher in HC (p&lt;0.001). The data point to a normalcy of renal reserve in ESHF which may depend on the chronic use of ACE inhibitors.<\/jats:p>","DOI":"10.1159\/000057414","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:20Z","timestamp":1050433580000},"page":"24-27","source":"Crossref","is-referenced-by-count":2,"title":["Renal Reserve Is Normal in Patients with Dilative Cardiomyopathy Waiting for Heart Transplantation"],"prefix":"10.1159","volume":"25","author":[{"given":"Annamaria","family":"Frangiosa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Spitali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Molino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleonora","family":"Cirillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"De Santo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Marra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciro","family":"Maiello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"De Vivo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Pascale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Favazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Di Leo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natale","family":"De Santo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Anastasio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[1999,4,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)91403-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(83)90873-2"}],"container-title":["Mineral and Electrolyte Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/57414","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/57414","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:58:25Z","timestamp":1745470705000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000057414"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":2,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[1999,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000057414","archive":["Portico"],"relation":{},"ISSN":["0378-0392","1423-016X"],"issn-type":[{"type":"print","value":"0378-0392"},{"type":"electronic","value":"1423-016X"}],"subject":[],"published":{"date-parts":[[1999]]}}}