{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:14:34Z","timestamp":1745554474637,"version":"3.40.4"},"reference-count":1,"publisher":"S. Karger AG","issue":"4-6","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mineral Electrolyte Metab"],"published-print":{"date-parts":[[1999]]},"abstract":"<jats:p>1,25(OH)&lt;sub&gt;2&lt;\/sub&gt;D&lt;sub&gt;3&lt;\/sub&gt; the biologically active metabolite of vitamin D is synthesized in the renal proximal tubules from the hepatic metabolite 25 (OH)D. Lack of 1,25(OH)&lt;sub&gt;2&lt;\/sub&gt;D&lt;sub&gt;3&lt;\/sub&gt; is relevant to the pathogenesis of secondary hyperparathyroidism, and 1,25(OH)&lt;sub&gt;2&lt;\/sub&gt;D&lt;sub&gt;3&lt;\/sub&gt; itself is used effectively in the management of renal failure patients to prevent secondary hyperparathyroidism. The scientific basis of this therapy is the finding that 1,25(OH)&lt;sub&gt;2&lt;\/sub&gt;D&lt;sub&gt;3&lt;\/sub&gt; potently decreases PTH gene transcription both in vitro and in vivo.<\/jats:p>","DOI":"10.1159\/000057471","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T19:06:20Z","timestamp":1050433580000},"page":"342-344","source":"Crossref","is-referenced-by-count":8,"title":["Transcriptional and Post-Transcriptional Regulation of PTH Gene Expression by Vitamin D, Calcium and Phosphate"],"prefix":"10.1159","volume":"25","author":[{"given":"Alin","family":"Sela-Brown","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tally","family":"Naveh-Many","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin","family":"Silver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2000,2,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.9.5253"}],"container-title":["Mineral and Electrolyte Metabolism"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/57471","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/57471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:58:51Z","timestamp":1745470731000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000057471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":1,"journal-issue":{"issue":"4-6","published-online":{"date-parts":[[1999,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000057471","archive":["Portico"],"relation":{},"ISSN":["0378-0392","1423-016X"],"issn-type":[{"type":"print","value":"0378-0392"},{"type":"electronic","value":"1423-016X"}],"subject":[],"published":{"date-parts":[[1999]]}}}