{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:02:10Z","timestamp":1791453730787,"version":"4.3.3"},"reference-count":10,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The immunologic characterization of chronic idiopathic urticaria (CIU) is still incomplete. In particular, it is not known if positivity to the intradermal autologous serum skin test (ASST) identifies an immunologic subset of CIU patients. &lt;i&gt;Methods:&lt;\/i&gt; Nineteen CIU patients and 15 healthy controls were enrolled in the study. A diagnostic flowchart was designed to select CIU patients, who were then analyzed by ASST. Cytokine and chemokine production and the expression of adhesion molecules was measured in patients and controls. &lt;i&gt;Results:&lt;\/i&gt; In CIU patients compared to controls, it was found that (1) TNF-\u03b1, IL-10, MIP-1\u03b1 and RANTES production was augmented and IL-2 and INF-\u03b3 reduced, and (2)\u00a0CD44, CD11a and CD62L expression on CD4 and CD8 cells was augmented. Additionally, TNF-\u03b1 and chemokine production was significantly increased in CIU patients with a negative ASST (p\u2013; n = 10) compared to patients with a positive response to the test. &lt;i&gt;Conclusions:&lt;\/i&gt; The presence of an inflammatory process in CIU patients is suggested by the findings that the production of both TNF-\u03b1 and chemokines as well as the expression of adhesion molecules is increased in these patients. Similarly to what is seen in rheumatoid arthritis, augmented IL-10 production might be secondary to the attempt to hamper the inflammatory milieu. Immune profiles are particularly altered in CIU p\u2013 patients, in whom a more aggressive therapeutic strategy might be considered.<\/jats:p>","DOI":"10.1159\/000058004","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T21:05:17Z","timestamp":1050440717000},"page":"59-66","source":"Crossref","is-referenced-by-count":76,"title":["Immune Profiles of Patients with Chronic Idiopathic Urticaria"],"prefix":"10.1159","volume":"128","author":[{"given":"Stefania","family":"Piconi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daria","family":"Trabattoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Iemoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Fusi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Luisa","family":"Villa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Milazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mario","family":"Clerici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2002,5,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199506293322608"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199306033282204"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12338544"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.115484"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(94)90135-X"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.8.1.365"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038\/346425a0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90337-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.11.1.165"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2000.105706"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/58004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/58004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:57:27Z","timestamp":1745467047000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000058004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2002,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000058004","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002]]}}}