{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T19:55:52Z","timestamp":1760644552814,"version":"3.40.4"},"reference-count":1,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>Nitric oxide (NO)-mediated vasodilation is diminished in blood vessels of copper (Cu)-deficient rats. This study examined whether Cu deficiency affects blood pressure regulation via an effect on NO metabolism. Male, weanling rats were fed diets ranging from 0.4 to 7.2 mg Cu\/kg diet for 5 weeks. Blood pressure was measured via arterial cannulation before and after intravenous injection of N&lt;sup&gt;G&lt;\/sup&gt;-nitro-&lt;i&gt;L&lt;\/i&gt;-arginine methyl ester (&lt;i&gt;L&lt;\/i&gt;-NAME, 10 mg\/kg body weight), a NO synthase inhibitor. Plotting blood pressure against the liver Cu concentration (22\u2013241 nmol\/g) revealed that control mean arterial blood pressure (MAP; 104\u2013152 mm Hg) was not correlated with the liver Cu concentration. However, both MAP after &lt;i&gt;L&lt;\/i&gt;-NAME treatment (MAP&lt;sub&gt;1&lt;\/sub&gt;, 148\u2013190 mm Hg) and the elevation of MAP caused by &lt;i&gt;L&lt;\/i&gt;-NAME (\u0394MAP; 8\u201368 mm Hg) were positively correlated with the liver Cu concentration (r = 0.52 for MAP&lt;sub&gt;1&lt;\/sub&gt;, r = 0.42 for \u0394MAP; p &lt; 0.05). This finding suggests that NO plays a significant role in maintaining basal blood pressure in Cu-adequate rats that is impaired by Cu deficiency.<\/jats:p>","DOI":"10.1159\/000058040","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T21:05:17Z","timestamp":1050440717000},"page":"141-144","source":"Crossref","is-referenced-by-count":5,"title":["Dietary Copper Deficiency Reduces the Elevation of Blood Pressure Caused by Nitric Oxide Synthase Inhibition in Rats"],"prefix":"10.1159","volume":"65","author":[{"given":"Jack T.","family":"Saari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,6,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(84)90384-9"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/58040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/58040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:58:08Z","timestamp":1745467088000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000058040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":1,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2002,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000058040","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"type":"print","value":"0031-7012"},{"type":"electronic","value":"1423-0313"}],"subject":[],"published":{"date-parts":[[2002]]}}}