{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T13:50:01Z","timestamp":1779889801899,"version":"3.53.1"},"reference-count":7,"publisher":"S. Karger AG","issue":"Suppl. 2","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; Pubertal growth contributes to 15\u201318% of adult height. A blunted pubertal peak could contribute to short adult height in short children born with intrauterine growth retardation (IUGR). &lt;i&gt;Design and Methods:&lt;\/i&gt; Pubertal growth, from onset of puberty to final height, was investigated in 75 short IUGR children: 47 were treated with recombinant human growth hormone (GH) (tx) before pubertal onset (mean dose: 0.4 IU\/kg\/week); 28 were not treated (no-tx). They were compared with 98 normal children. &lt;i&gt;Results:&lt;\/i&gt; Puberty occurred later in IUGR children than in controls (boys 14.2 \u00b1 1 years vs. 12.1 \u00b1 0.8 years; girls 12 \u00b1 1 years vs. 11.2 \u00b1 0.8 years; p &lt; 0.0001). In girls, total pubertal growth was similar in all three groups (tx: 19.3 \u00b1 4.8 cm; no-tx 19.8 \u00b1 4.9 cm; controls 20.2 \u00b1 3.9 cm; non-significant). IUGR boys had a reduced pubertal growth (tx: 21.3 \u00b1 6.2 cm; no-tx: 23.9 \u00b1 6.1; controls 26.9 \u00b1 3.9 cm; p &lt; 0.05). The age at puberty onset was the major determinant of pubertal growth amplitude (boys: r = 0.53, p &lt; 0.001; girls: r = 0.45, p &lt; 0.001). IUGR children exhibited little catch-up growth during puberty. &lt;i&gt;Conclusions:&lt;\/i&gt; In the present study, we describe a delayed onset of puberty in short children born with IUGR. Moreover, prepubertal GH treatment was associated in boys with a decrease in the amplitude of the pubertal spurt, a finding that should be further evaluated in clinical trials.<\/jats:p>","DOI":"10.1159\/000058108","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T13:07:10Z","timestamp":1050412030000},"page":"88-94","source":"Crossref","is-referenced-by-count":21,"title":["Amplitude of Pubertal Growth in Short Stature Children with Intrauterine Growth Retardation"],"prefix":"10.1159","volume":"57","author":[{"given":"Anne","family":"Lienhardt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Carel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Marie","family":"Preux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00e9gis","family":"Coutant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Louis","family":"Chaussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2004,11,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91224-A"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-199908000-00013"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.78.6.1454"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.81.5.1887"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.9.3064"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.4.1070"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000023375"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/58108","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/58108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:58:48Z","timestamp":1745467128000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000058108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":7,"journal-issue":{"issue":"Suppl. 2","published-online":{"date-parts":[[2002,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000058108","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002]]}}}