{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T16:13:19Z","timestamp":1774714399017,"version":"3.50.1"},"reference-count":3,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; The purpose of this study was to evaluate the clinical efficacy, histopathological efficacy, and response to preoperative thermochemoradiotherapy for N&lt;sub&gt;3&lt;\/sub&gt; cervical lymph node metastases of oral cancer. &lt;i&gt;Methods:&lt;\/i&gt; Preoperative thermochemoradiotherapy was performed in 8 patients with oral cancer and N&lt;sub&gt;3&lt;\/sub&gt; cervical lymph node metastasis. These patients underwent four-weekly sessions of hyperthermia, combined with radiotherapy (40\u00a0Gy) as well as chemotherapy with cisplatin (CDDP; 100\u00a0mg\/m&lt;sup&gt;2&lt;\/sup&gt;), all prior to surgery. Radical neck dissection was performed 4 weeks after completion of preoperative thermochemoradiotherapy. &lt;i&gt;Results:&lt;\/i&gt; The preoperative treatment of cervical lymph node metastases yielded a partial response in 6 patients, while 2 patients demonstrated no change. Histopathologically, grade III was detected in 1, grade IIb in 4 and grade IIa in 3 patients after surgery, according to the criteria of Shimosato. The follow-up period ranged from 13 to 64 months (mean 34). Of the 8 patients, 2 died (1 of lymph node metastasis and 1 had metastasis to a distant site), and 6 patients were alive at the last follow-up, with the longest postoperative disease-free survival being 63 months. The 5-year cumulative survival rate was 70.0%. &lt;i&gt;Conclusion:&lt;\/i&gt; These results indicate that preoperative thermochemoradiotherapy is a promising modality for patients with N&lt;sub&gt;3&lt;\/sub&gt; cervical lymph node metastasis of oral cancer.<\/jats:p>","DOI":"10.1159\/000059571","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T21:05:17Z","timestamp":1050440717000},"page":"234-240","source":"Crossref","is-referenced-by-count":17,"title":["Prognostic Evaluation of Preoperative Thermochemoradiotherapy for N&lt;sub&gt;3&lt;\/sub&gt; Cervical Lymph Node Metastases of Oral Cancer"],"prefix":"10.1159","volume":"62","author":[{"given":"Iwai","family":"Tohnai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Mitsudo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Shigetomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minoru","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Ishigaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,6,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1080\/026567399285567"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9098(199612)63:4<240::AID-JSO5>3.3.CO;2-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000901)89:5<939::AID-CNCR1>3.0.CO;2-6"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/59571","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/59571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:03:04Z","timestamp":1745467384000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000059571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":3,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2002,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000059571","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002]]}}}