{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T07:00:31Z","timestamp":1767855631581,"version":"3.49.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>Novel human estrogen receptor (ER)-\u03b2 was identified in cDNA libraries from human testes. ER-\u03b2 specifically expresses in the testis, ovary, thymus, spleen, osteoblasts, fetus and uterine endometrium. ER-\u03b2 might not conserve the same physiological functions as does ER-\u03b1. Therefore, expressions of ER-\u03b1 and ER-\u03b2 mRNAs in primary and metastatic lesions of uterine endometrial cancers were investigated. The levels of ER-\u03b2 mRNA were significantly lower than those of ER-\u03b1 mRNA in uterine endometrial cancers and in normal uterine endometria. The ratio of ER-\u03b2 to ER-\u03b1 mRNA in most primary uterine endometrial cancers was similar to that in normal uterine endometria (&lt;0.4% of ER-\u03b2 mRNA to ER-\u03b1 mRNA). On the other hand, in 14 of the 20 lymph node metastasis-positive cases of uterine endometrial cancers, the ratio in the metastatic lesion was significantly higher than that in the primary lesion of the corresponding case, and patient prognosis in these cases was extremely poor. Therefore, it is suggested that the intact synchronized expression of ER-\u03b2 interacting with ER-\u03b1 might be disrupted, especially in most metastases of uterine endometrial cancers, leading to poor patient prognosis related to estrogen refractoriness.<\/jats:p>","DOI":"10.1159\/000059575","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T21:05:17Z","timestamp":1050440717000},"page":"269-277","source":"Crossref","is-referenced-by-count":31,"title":["Clinical Implications of the Expression of Estrogen Receptor-\u03b1 and -\u03b2 in Primary and Metastatic Lesions of Uterine Endometrial Cancers"],"prefix":"10.1159","volume":"62","author":[{"given":"Jiro","family":"Fujimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Sakaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ikumi","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Toyoki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruhiko","family":"Tamaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,6,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81118-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90199-X"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.12.5925"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.3.863"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/me.11.3.353"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5331.1508"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.10.3509"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210\/en.137.11.4796"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.4.1476"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210\/en.138.11.4613"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1987.9999"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2264(199812)23:4<361::AID-GCC12>3.0.CO;2-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.10.5722"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000012121"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/59575","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/59575","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:03:06Z","timestamp":1745467386000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000059575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":14,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2002,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000059575","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"value":"0030-2414","type":"print"},{"value":"1423-0232","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002]]}}}