{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:12:10Z","timestamp":1767168730276,"version":"build-2238731810"},"reference-count":4,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2000]]},"abstract":"<jats:p>Multidisciplinary advances in skeletal physiology offer a new paradigm for the effects of growth hormone (GH) and other agents on bone and osteoporosis. The still-evolving Utah paradigm of skeletal physiology supplements earlier ideas with later discovered roles of the skeleton\u2019s tissue-level \u2018nephron equivalents\u2019 and muscle strength in skeletal development, physiology and disorders. This article summarizes how these factors could influence the effects of GH on bone strength and bone \u2018mass\u2019, and the use of GH in the treatment of osteoporoses. Although the cellular and molecular biological mechanisms involved remain obscure, the associated cascades of cellular, genetic and biochemical processes and molecules should offer many opportunities to find or design agents that have medically useful effects on bone and muscle without giving rise to unwanted side-effects.<\/jats:p>","DOI":"10.1159\/000063446","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T15:06:15Z","timestamp":1050419175000},"page":"36-43","source":"Crossref","is-referenced-by-count":13,"title":["Growth Hormone and Osteoporosis: An Overview of Endocrinological and Pharmacological Insights from the Utah Paradigm of Skeletal Physiology"],"prefix":"10.1159","volume":"54","author":[{"given":"Harold M.","family":"Frost","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,11,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900399"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1385\/JCD:1:1:41"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1126\/science.285.5433.1553"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/jama.281.20.1895"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/63446","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/63446","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:09:09Z","timestamp":1745453349000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000063446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":4,"aliases":["10.1159\/000053296"],"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2000,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000063446","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000]]}}}