{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:12:43Z","timestamp":1745554363834,"version":"3.40.4"},"reference-count":7,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To assess the risk to second- and third-borns of developing perinatal infections based on a diminished first-line immune response in comparison to the first-born. &lt;i&gt;Study Design:&lt;\/i&gt; 11 sets of twins and 2 sets of triplets (27\u201339 weeks of gestation, 740\u20133,560\u00a0g birth weight) admitted consecutively to our neonatal care unit were investigated. All were delivered by cesarean section. Phagocytosis and the expression of TNF-\u03b1 and IL-1 in cord blood were determined immediately and 72 h after birth from peripheral blood monocytes by FACS analysis and ELISA. &lt;i&gt;Results:&lt;\/i&gt; In all second- and third-borns, phagocytosis of cord blood monocytes was significantly decreased in comparison to the first-borns (p &lt; 0.001, p &lt; 0.015). 72\u00a0h after birth phagocytosis determined from peripheral blood showed no significant difference between the first-borns and the second- and third-borns. Cytokine expression revealed no significant differences dependent on birth order. &lt;i&gt;Conclusion:&lt;\/i&gt; We suggest that the observed temporarily diminished first-line immune response of second- and third-born multiplets might be the result of a short-term reduced cellular oxygenation during delivery, but has no influence on further immunological deficiency leading to a higher risk of perinatal infections.<\/jats:p>","DOI":"10.1159\/000064149","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T21:05:17Z","timestamp":1050440717000},"page":"29-33","source":"Crossref","is-referenced-by-count":2,"title":["Decreased Phagocytic Capacity of Cord Blood Monocytes in Second- and Third-Born Multiplets"],"prefix":"10.1159","volume":"82","author":[{"given":"Gerhard","family":"Pomberger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrike","family":"Hallwirth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heinz","family":"Strohmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Spittler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Wald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Zaknun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,7,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2000.105132"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199407283310407"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.105346"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-199703000-00024"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199907)29:07<2280::AID-IMMU2280>3.0.CO;2-C"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.1.56"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/1043-4666(91)90015-6"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/64149","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/64149","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:16:58Z","timestamp":1745468218000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000064149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":7,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2002,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000064149","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2002]]}}}