{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:40:03Z","timestamp":1745469603230,"version":"3.40.4"},"reference-count":7,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>Pretreatment of mice with a subcutaneous (s.c.) injection of LiCl (1, 3, 10 mmol\/kg) 18 h prior to testing produced dose-related attenuation of the reciprocal hindlimb scratching (RHS) response induced by intrathecal (i.t.) administration of pilocarpine. LiCl (10 mmol\/kg, 424 mg\/kg) pretreatment shifted the pilocarpine (2 \u00b5g)-induced RHS dose-response curve about 5-fold to the right compared to vehicle-injected controls (ED&lt;sub&gt;50&lt;\/sub&gt; = 2.97 and 0.56\u00a0 \u00b5g, respectively). Coadministration of inositol-1,4,5-trisphosphate (IP&lt;sub&gt;3&lt;\/sub&gt;; 5, 10, 20 \u00b5g), but not inositol hexaphosphate (0.03\u20133 \u00b5g), myo-inositol (10 \u00b5g) or EDTA (1.33 \u00b5g), produced dose-related reversal of the LiCl effect. IP&lt;sub&gt;3&lt;\/sub&gt; administration alone neither produced RHS nor enhanced the pilocarpine-induced RHS in animals not pretreated with LiCl. These findings provide in vivo evidence for a possible link between RHS and a LiCl-sensitive, possibly phosphoinositide-related, effector pathway.<\/jats:p>","DOI":"10.1159\/000064346","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T21:05:17Z","timestamp":1050440717000},"page":"210-214","source":"Crossref","is-referenced-by-count":1,"title":["LiCl Attenuates M&lt;sub&gt;1&lt;\/sub&gt;AChR-Mediated Intrathecal Pilocarpine-Induced Reciprocal Hindlimb Scratching in Mice"],"prefix":"10.1159","volume":"65","author":[{"given":"Rebecca P.","family":"Martinez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert B.","family":"Raffa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,7,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(87)90126-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(87)90702-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(88)90082-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.29.1.71"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(92)90060-H"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(80)90515-4"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(83)90379-5"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/64346","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/64346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:19:06Z","timestamp":1745468346000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000064346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":7,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2002,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000064346","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"type":"print","value":"0031-7012"},{"type":"electronic","value":"1423-0313"}],"subject":[],"published":{"date-parts":[[2002]]}}}