{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:20:37Z","timestamp":1778901637047,"version":"3.51.4"},"reference-count":6,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>&lt;i&gt;Objectives:&lt;\/i&gt; To investigate the cognitive effects of high-dose oral estrogen alone or in combination with oral methyltestosterone in postmenopausal women. &lt;i&gt;Methods:&lt;\/i&gt; Participants were tested with a randomized, double-blind design on the Identical Pictures, Cube Comparisons, Building Memory and Shape Memory tasks before and after 4 months of hormone treatment. &lt;i&gt;Results:&lt;\/i&gt; Women receiving estrogen and methyltestosterone maintained a steady level of performance on the Building Memory task, whereas those receiving estrogen alone showed a decrease in performance. &lt;i&gt;Conclusions:&lt;\/i&gt; These results indicate that the addition of testosterone to high-dose estrogen replacement exerts a protective effect on memory performance in postmenopausal women.<\/jats:p>","DOI":"10.1159\/000064491","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T12:11:24Z","timestamp":1050408684000},"page":"150-155","source":"Crossref","is-referenced-by-count":12,"title":["Evaluation of High-Dose Estrogen and High-Dose Estrogen plus Methyltestosterone Treatment on Cognitive Task Performance in Postmenopausal Women"],"prefix":"10.1159","volume":"58","author":[{"given":"Amy B.","family":"Wisniewski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tam T.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian S.","family":"Dobs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,9,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(91)90018-O"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1037\/\/0012-1649.22.2.191"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(88)90060-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.7.2363"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0191-8869(93)90174-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0162-3095(94)90020-5"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/64491","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/64491","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:20:37Z","timestamp":1745468437000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000064491"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2002,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000064491","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002]]}}}