{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:26:34Z","timestamp":1761647194901,"version":"3.40.4"},"reference-count":1,"publisher":"S. Karger AG","issue":"Suppl. 1","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>In children who depend on long-term parenteral nutrition (PN), a major goal is to obtain optimal growth. The aim of this retrospective study was to analyze growth in children on long-term cyclic nocturnal home PN, over at least 8 years before puberty. Nine boys and 7 girls were studied. Their mean age at the time of study was 11 years with a mean PN duration of 10.5 (8.6\u201316.4) years. Diseases were short bowel syndrome (5), intractable diarrhea (4), chronic intestinal pseudo-obstruction (4) and long segment Hirschsprung\u2019s disease (3). In each child, periods of at least 2 years were analyzed: either periods of regular growth (R: height gain &gt;50th percentile), or slow growth (S: height gain \u226425th percentile). Results were expressed as mean \u00b1 SD. Comparisons were performed using either Student\u2019s test for unpaired data or Wilcoxon\u2019s test for paired data. PN provided a mean of 224 \u00b1 80 mg nitrogen\/kg\/day and 43 \u00b1 14 kcal\/kg\/day equivalent to 50% of recommended supplies. At the time of study, the population presented with weight (W) = \u20130.7 \u00b1 0.8 SD and height (H) = \u20131.5 \u00b1 1.3 SD. The difference between W and expected W for H (W\/H) was significant (p &lt; 0.002). W\/H ratio was 105 \u00b1 11%. For the total PN duration, weight gain was +0.2 \u00b1 1.5 SD and height loss was \u20130.75 \u00b1 1.4 SD. An excess weight gain occurred in parallel with the deflection of height gain. Of the 16 children, regular prepubertal growth was achieved in 4 only. The other 12 showed alternate periods of R and S. In 8 of them, 26.5 years of R and 33.5 years of S were compared, each child being his own control. PN nitrogen and energy supplies were significantly higher during R periods than during S periods. In the absence of any disease or treatment explaining the failure to thrive, inadequate PN supplies, especially in terms of nitrogen supply, are thought to be responsible for a negative nitrogen balance and slowed growth. In case of any deflection away from the individual growth curve, it is recommended to adjust the PN supply early, especially nitrogen supply.<\/jats:p>","DOI":"10.1159\/000064760","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T21:05:17Z","timestamp":1050440717000},"page":"2-6","source":"Crossref","is-referenced-by-count":7,"title":["Prepubertal Growth in Children with Long-Term Parenteral Nutrition"],"prefix":"10.1159","volume":"58","author":[{"given":"V.","family":"Colomb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Dabbas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Goulet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Talbotec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Corriol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Ricour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,11,17]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1054\/clnu.2000.0132"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/64760","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/64760","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:23:03Z","timestamp":1745468583000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000064760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":1,"journal-issue":{"issue":"Suppl. 1","published-online":{"date-parts":[[2002,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000064760","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2002]]}}}