{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:13:01Z","timestamp":1745554381160,"version":"3.40.4"},"reference-count":4,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gyn\u00e4kol Geburtshilfliche Rundsch"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>&lt;i&gt;Fragestellung:&lt;\/i&gt; Eine retrospektive Analyse der Wertigkeit einer sogenannten Second-look-Operation bezogen auf das krankheitsfreie und Gesamt\u00fcberleben bei Patientinnen mit einem Ovarialkarzinom oder Tubenkarzinom. &lt;i&gt;Methode:&lt;\/i&gt; Bei einem Gesamtkollektiv von 469 Patientinnen wurden bei 208 Patientinnen mit und ohne Second- look-Operation eine gepaarte Analyse durchgef\u00fchrt und im Rahmen einer Multivariatanalyse ein Cox-Regressionsmodell erstellt. &lt;i&gt;Ergebnisse:&lt;\/i&gt; Es konnte bez\u00fcglich krankheitsfreiem Intervall und Gesamt\u00fcberleben kein signifikanter Unterschied zwischen Patientinnen mit und ohne Second-look-Operation festgestellt werden. Die 10-Jahres-\u00dcberlebensrate war bei beiden verglichenen Gruppen praktisch identisch. &lt;i&gt;Schlussfolgerungen:&lt;\/i&gt; Die Second-look-Operation ist aufgrund der Aussagef\u00e4higkeit von klinisch nichtinvasiven Methoden wie Bildgebung in Kombination mit dem Tumormarker CA-125 und der mangelnden Effizienz einer Second-line-Therapie nicht als Routineeingriff gerechtfertigt und soll nur ausgew\u00e4hlten klinischen Studien, zur Evaluierung neuer Behandlungsmethoden, vorbehalten sein.<\/jats:p>","DOI":"10.1159\/000065152","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T21:05:17Z","timestamp":1050440717000},"page":"217-224","source":"Crossref","is-referenced-by-count":2,"title":["Die Wertigkeit der Second-Look-Operation bei Patientinnen mit einem Ovarialkarzinom oder Tubenkarzinom mittels einer retrospektiven Vergleichsstudie"],"prefix":"10.1159","volume":"42","author":[{"given":"H.W.","family":"Ott","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Illmensee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zeimet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Mueller-Holzner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Windbichler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Eibl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Marth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,10,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199503093321002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.6036"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.106250"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/1098-2388(200007\/08)19:1<54::AID-SSU9>3.0.CO;2-9"}],"container-title":["Gyn\u00e4kologisch-geburtshilfliche Rundschau"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/65152","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/65152","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:27:27Z","timestamp":1745468847000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000065152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":4,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2002,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000065152","archive":["Portico"],"relation":{},"ISSN":["1018-8843","1423-0011"],"issn-type":[{"type":"print","value":"1018-8843"},{"type":"electronic","value":"1423-0011"}],"subject":[],"published":{"date-parts":[[2002]]}}}