{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T17:30:35Z","timestamp":1774459835246,"version":"3.50.1"},"reference-count":7,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; The purpose of this study was to evaluate whether abnormal levels of first trimester maternal serum free human chorionic gonadotropin (\u03b2-hCG) are predictive of adverse pregnancy outcomes. &lt;i&gt;Methods:&lt;\/i&gt; The study included 1,622 consecutive patients with singleton pregnancies who underwent first trimester Down syndrome screening using nuchal translucency, and maternal serum free \u03b2-hCG and pregnancy-associated plasma protein-A. Patients with fetal anomalies or chromosome aberrations were excluded from the study. The incidences of various adverse pregnancy outcomes were evaluated according to maternal serum free \u03b2-hCG levels. Outcome variables included spontaneous miscarriage, proteinuric and non-proteinuric pregnancy-induced hypertension, fetal growth restriction, intrauterine fetal demise, spontaneous preterm delivery, oligohydramnios and placental abruption. &lt;i&gt;Results:&lt;\/i&gt; No significant differences were noted between groups for any of the demographic variables. The only statistically significant result was an increase in the relative risk for spontaneous miscarriage (RR = 6.33) at free \u03b2-hCG &lt;0.2 multiples of the medians. No other statistically significant result was noted for the other adverse outcomes or for the overall complication rate. &lt;i&gt;Conclusion:&lt;\/i&gt; Low free \u03b2-hCG is associated with a higher incidence of spontaneous miscarriage but is a poor predictor of other pregnancy complications.<\/jats:p>","DOI":"10.1159\/000065384","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T21:05:17Z","timestamp":1050440717000},"page":"352-356","source":"Crossref","is-referenced-by-count":57,"title":["First Trimester Maternal Serum Free Human Chorionic Gonadotropin as a Predictor of Adverse Pregnancy Outcome"],"prefix":"10.1159","volume":"17","author":[{"given":"Yuval","family":"Yaron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifat","family":"Ochshorn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sigal","family":"Heifetz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ofer","family":"Lehavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaron","family":"Sapir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avi","family":"Orr-Urtreger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,10,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199912303412701"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(99)00467-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0223(200009)20:9<738::AID-PD917>3.0.CO;2-R"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0223(200008)20:8<652::AID-PD882>3.0.CO;2-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199902)19:2<122::AID-PD491>3.0.CO;2-R"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-0705.1999.13010058.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199802)18:2<147::AID-PD231>3.0.CO;2-W"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/65384","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/65384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:29:30Z","timestamp":1745468970000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000065384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":7,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2002,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000065384","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002]]}}}