{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:49:10Z","timestamp":1761511750267,"version":"3.40.4"},"reference-count":8,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>&lt;i&gt;Aim: &lt;\/i&gt;The aim of this study was to estimate the lipolytic activity of the human growth hormone variant, 20-kD human growth hormone (20K-hGH). &lt;i&gt;Methods:&lt;\/i&gt; Obese KV-A&lt;sup&gt;&lt;i&gt;y&lt;\/i&gt;&lt;\/sup&gt; mice were given daily subcutaneous injections of 20K-hGH (0.25, 0.5, 1.0\u00a0mg\/kg), 22K-hGH (0.25\u00a0mg\/kg) or saline as a control for 2 weeks. Body composition (fat, water and protein), lipolysis and lipoprotein lipase (LPL) activity were measured 24\u00a0h after the final injection. &lt;i&gt;Results:&lt;\/i&gt; Both growth hormone isoforms significantly reduced relative fat pad and whole body lipids. In addition, 20K-hGH produced an inhibition of LPL activity in adipose tissue and stimulated lipolysis in adipocytes. &lt;i&gt;Conclusion:&lt;\/i&gt; These data strongly suggest that inhibition of LPL activity in adipose tissue and stimulation of lipolysis in adipocytes by 20K-hGH treatment reduce adipose tissue mass, resulting in body fat reduction.<\/jats:p>","DOI":"10.1159\/000065488","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T21:05:17Z","timestamp":1050440717000},"page":"157-164","source":"Crossref","is-referenced-by-count":4,"title":["The 20-kD Human Growth Hormone Reduces Body Fat by Increasing Lipolysis and Decreasing Lipoprotein Lipase Activity"],"prefix":"10.1159","volume":"58","author":[{"given":"Shunichi","family":"Takahashi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noboru","family":"Satozawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,9,19]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1210\/jc.84.1.98"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1054\/ghir.2000.0149"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1054\/ghir.2001.0198"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1016\/0140-6736(90)91812-O"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1016\/0140-6736(92)92892-J"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1054\/ghir.2000.0153"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1016\/0024-3205(94)00512-5"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1016\/0024-3205(81)90553-1"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/65488","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/65488","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:30:45Z","timestamp":1745469045000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000065488"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":8,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2002,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000065488","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2002]]}}}