{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T19:48:10Z","timestamp":1778874490672,"version":"3.51.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cells Tissues Organs"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>Genetically manipulated human keratinocytes can produce and secrete medically relevant proteins to the circulation. Genetically modified skin may also function as a \u2018metabolic sink\u2019 detoxifying the body of metabolites which accumulate in certain metabolic diseases. At the National Institutes of Health (NIH), Bethesda, Md., a clinical trial investigating the treatment of an ocular disease using the skin as a \u2018metabolic sink\u2019 for ornithine accumulating in gyrate atrophy patients is being prepared. The trial will involve the transplantation of a small patch of autologous keratinocytes, transduced ex vivo, onto the thighs of patients with gyrate atrophy. We are now investigating other diseases where this technology may be applicable such as in the treatment of hyperphenylalaninemia or hypercholesterolemia.<\/jats:p>","DOI":"10.1159\/000065612","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T21:05:17Z","timestamp":1050440717000},"page":"96-104","source":"Crossref","is-referenced-by-count":8,"title":["Skin Genetically Engineered as a Bioreactor or a \u2018Metabolic Sink\u2019"],"prefix":"10.1159","volume":"172","author":[{"given":"Rikke","family":"Christensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uffe Birk","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas G.","family":"Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,11,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt1297-1388"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038\/ng0293-180"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300653"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.8.4356"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300689"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.19.10371"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1089\/10430349950016546"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3300505"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.1.219"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(1998)12:5<344::AID-HUMU8>3.0.CO;2-D"}],"container-title":["Cells Tissues Organs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/65612","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/65612","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:32:11Z","timestamp":1745469131000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000065612"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2002,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000065612","archive":["Portico"],"relation":{},"ISSN":["1422-6405","1422-6421"],"issn-type":[{"value":"1422-6405","type":"print"},{"value":"1422-6421","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002]]}}}