{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:13:13Z","timestamp":1745554393535,"version":"3.40.4"},"reference-count":2,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>The goal of the current study was to examine the effect of the kappa-opioid agonist, bremazocine (BRE), on inositol phosphate (IP) formation in the rabbit iris-ciliary body (ICB). Concentrations of BRE (10&lt;sup&gt;\u20137&lt;\/sup&gt; to 10&lt;sup&gt;\u20135&lt;\/sup&gt;&lt;i&gt;M&lt;\/i&gt;) augmented levels of IP. Incubation of ICBs with BRE (10&lt;sup&gt;\u20136&lt;\/sup&gt;&lt;i&gt;M&lt;\/i&gt;) produced a time-dependent increase in IP levels that peaked at 60 s and declined to basal levels by 5 min. The increase in IP levels produced by BRE (10&lt;sup&gt;\u20136&lt;\/sup&gt;&lt;i&gt;M&lt;\/i&gt;) was inhibited by the kappa-opioid receptor antagonist, nor-binaltorphimine (nor-BNI, 10&lt;sup&gt;\u20137&lt;\/sup&gt; to 10&lt;sup&gt;\u20135&lt;\/sup&gt;&lt;i&gt;M&lt;\/i&gt;) and by activation of PKC with PDBu (10&lt;sup&gt;\u20137&lt;\/sup&gt;&lt;i&gt;M&lt;\/i&gt;). These results demonstrate that kappa-opioid receptor activation by BRE in the rabbit ICB is linked to IP production. Thus, opioid agonist-induced increases in IP activity could play a role in BRE-induced increases in atrial natriuretic peptide release and alterations in aqueous humor dynamics.<\/jats:p>","DOI":"10.1159\/000065632","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T21:05:17Z","timestamp":1050440717000},"page":"100-106","source":"Crossref","is-referenced-by-count":3,"title":["Effect of Bremazocine, a Kappa-Opioid Receptor Agonist, on Inositol Phosphate Formation in Isolated Iris-Ciliary Bodies"],"prefix":"10.1159","volume":"66","author":[{"given":"Juanita","family":"Dortch-Carnes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Potter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,9,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1006\/exer.1994.1121"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90050-2"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/65632","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/65632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:32:20Z","timestamp":1745469140000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000065632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":2,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2002,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000065632","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"type":"print","value":"0031-7012"},{"type":"electronic","value":"1423-0313"}],"subject":[],"published":{"date-parts":[[2002]]}}}