{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T05:44:55Z","timestamp":1761630295178,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The etiopathology of chronic eczematous lesions of the palms and\/or soles remains elusive in a considerable proportion of patients. Accumulating evidence suggests that a rare variant of mycosis fungoides (MF)-type cutaneous T cell lymphoma (CTCL) restricted to the palms and\/or soles may mimic common palmoplantar dermatoses. &lt;i&gt;Objective:&lt;\/i&gt; In the present study, we analyzed the clinical and histological characteristics of 3 adult patients with preexisting nonclassified chronic palmoplantar eczema poorly responding to standard therapies. Palmar and\/or plantar MF was eventually diagnosed. &lt;i&gt;Methods:&lt;\/i&gt; The course of the disease, response to previous therapies and dermatological features are described, results of histochemical and immunohistochemical analyses are reported, including T cell receptor \u03b3 gene rearrangement where obtainable. &lt;i&gt;Results:&lt;\/i&gt; Onset of cutaneous lesions with broad clinical variation was experienced 2\u201310 years prior to diagnosis; conventional therapies led to short-time or partial remission only; except for 1 patient, the epidermotropic infiltrate was predominantly composed of CD4-positive cells; topical photochemotherapy seems to result in more durable responses. &lt;i&gt;Conclusion:&lt;\/i&gt; As therapeutic strategies for this disease variant differ from symptomatic standard treatment regimens, awareness of MF-type CTCL as a relevant differential diagnosis of palmoplantar eczema should be expanded to prevent delay in diagnosis and adequate therapy.<\/jats:p>","DOI":"10.1159\/000065862","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T10:10:37Z","timestamp":1050401437000},"page":"239-244","source":"Crossref","is-referenced-by-count":22,"title":["Mycosis-fungoides-Type Cutaneous T Cell Lymphoma of the Hands and Soles: A Variant Causing Delay in Diagnosis and Adequate Treatment of Patients with Palmoplantar Eczema"],"prefix":"10.1159","volume":"205","author":[{"given":"Konstanze","family":"Spieth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcella","family":"Grundmann-Kollmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Runne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyde","family":"Staib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Fellbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Wolter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Kaufmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Gille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,10,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.131.9.1052"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050384"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.105503"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000051542"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.125.3.402"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.131.3.325"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199806000-00009"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.120.8.1045"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.113.9.1254"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.132.8.971"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.132.4.468"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199912000-00003"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/65862","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/65862","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:10:20Z","timestamp":1745464220000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000065862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2002,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000065862","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2002]]}}}