{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T07:04:03Z","timestamp":1778396643965,"version":"3.51.4"},"reference-count":7,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2002]]},"abstract":"<i>Aim:<\/i> To analyze whether bone mineral density (BMD) and bone resorption status are influenced by long-term metabolic control and duration of disease in adolescents with long-standing type 1 diabetes mellitus. <i>Methods:<\/i> Twenty-seven adolescents (age 13.1 \u00b1 1.7 years, duration of diabetes 6.9 \u00b1 3.0 years) were studied. The BMD, expressed as z score, was measured at the lumbar spine (L1\u2013L4) using dual-energy X-ray absorptiometry, while the urinary excretion of total deoxypiridinoline (Dpyd), a marker of bone resorption, was measured by immunoassay and was corrected by creatinine (Cr). Linear and multivariate correlations between lumbar BMD z score or Dpyd\/Cr excretion and age and disease variables [short-term (Hb A<sub>1clatest<\/sub>) or long-term (Hb A<sub>1cwholeduration<\/sub>) metabolic control, duration, \u2018diabetes impact index\u2019 (mean Hb A<sub>1cwholeduration<\/sub> x duration of disease in months)] were sought. <i>Results:<\/i> In diabetic subjects the mean BMD z score was \u20130.44 \u00b1 (SD) 1.02 (95% CI: \u20130.03; \u20130.84), and the Dpyd\/Cr excretion was not increased. A negative correlation was found between lumbar BMD z score and age (r \u20130.59; p = 0.001), duration (r \u20130.39; p = 0.04), and the diabetes impact index (r \u20130.4; p = 0.04). The Dpyd\/Cr ratio correlated negatively with age (r \u20130.40; p = 0.04) and positively with height velocity (r 0.42; p = 0.04). By using multiple linear regression, age showed a significant inverse correlation with lumbar BMD z score (\u03b2 = \u20130.39; p = 0.0005). A negative correlation was found between lumbar BMD z score and Hb A<sub>1cwholeduration<\/sub> (\u03b2 = \u20130.40; p = 0.02) or diabetes impact index (\u03b2 = \u20130.001; p = 0.01). <i>Conclusions:<\/i> Poor metabolic control may expose adolescents with long-standing type 1 diabetes to the risk of developing osteopenia in adult age. Optimization of metabolic control in growing diabetic children may prevent osteoporosis in later life.<\/jats:p>","DOI":"10.1159\/000066441","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T12:11:24Z","timestamp":1050408684000},"page":"266-272","source":"Crossref","is-referenced-by-count":76,"title":["The Lumbar Bone Mineral Density Is Affected by Long-Term Poor Metabolic Control in Adolescents with Type 1 Diabetes mellitus"],"prefix":"10.1159","volume":"58","author":[{"given":"Giuliana","family":"Valerio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"del Puente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Esposito-del Puente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Buono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Mozzillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Franzese","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,11,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000023273"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.80.4.1194"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/er.17.4.333"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000023353"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s002239900390"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s001980050082"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1998.00374.x"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/66441","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/66441","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:16:21Z","timestamp":1745464581000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000066441"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":7,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2002,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000066441","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002]]}}}