{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T15:09:46Z","timestamp":1760368186046,"version":"3.40.4"},"reference-count":9,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Genome Res"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>We have characterised a 2.4-Mb genomic sequence of a smallest region of overlap (SRO) deleted in the human microdeletion syndrome 7p21 by &lt;i&gt;in silico&lt;\/i&gt; analysis. Patients harbouring this minimal deletion present in addition to the clinical features of Saethre-Chotzen syndrome (MIM 101400) a distinct learning disability. This genomic region shows a very low gene content. Besides the transcription factor gene TWIST, the Histone Deacetylase 9 (HDAC9), Sorting Nexin 13 (SNX13) and an evolutionarily conserved bHLH transcription factor gene Nephew of Atonal 3 (HNATO3) have been detected previously. Here we describe the localisation and characterisation of the TWIST NEIGHBOR (TWISTNB) gene. Comparison of the predicted proteins of human TWISTNB and mouse &lt;i&gt;Twistnb&lt;\/i&gt; shows a high degree of conservation. Northern blot analysis of human fetal and adult tissues shows ubiquitous expression in all tissues tested.\u00a0\u00a0\u00a0<\/jats:p>","DOI":"10.1159\/000066618","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T21:05:40Z","timestamp":1050440740000},"page":"167-170","source":"Crossref","is-referenced-by-count":11,"title":["Identification and characterisation of the gene TWIST NEIGHBOR (TWISTNB) located in the microdeletion syndrome 7p21 region"],"prefix":"10.1159","volume":"97","author":[{"given":"C.","family":"Kosan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kunz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,11,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-42"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-200103000-00003"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/ng0197-36"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1086\/302122"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1119(90)90087-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0925-4773(01)00437-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007364200"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1126\/science.1064757"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.191375098"}],"container-title":["Cytogenetic and Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/66618","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/66618","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:17:40Z","timestamp":1745464660000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000066618"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":9,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2002,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000066618","archive":["Portico"],"relation":{},"ISSN":["1424-8581","1424-859X"],"issn-type":[{"type":"print","value":"1424-8581"},{"type":"electronic","value":"1424-859X"}],"subject":[],"published":{"date-parts":[[2002]]}}}