{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:21:08Z","timestamp":1759962068093,"version":"3.40.4"},"reference-count":4,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2002,12,5]],"date-time":"2002-12-05T00:00:00Z","timestamp":1039046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,12,5]],"date-time":"2002-12-05T00:00:00Z","timestamp":1039046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>The Clinician\u2019s Interview Based Impression of Change, plus carer interview (CIBIC-Plus) is widely used in anti-dementia drug trials. It includes clinicians\u2019 notes about patients\u2019 behaviour, function, and cognition, and a 7-point clinical global impression of change scale that summarizes patients\u2019 changes during treatment. We analyzed the narrative content of clinicians\u2019 notes from a randomized, controlled trial of galantamine, an anti-Alzheimer\u2019s disease drug, and identified varying degrees of improvement and decline. In general, while most patients were rated as showing \u2018no change\u2019, considerable changes were seen in such patients, but were judged by clinicians to have been offset by decline in other areas. Most patients rated as \u2018improved\u2019 showed combinations of cognitive, functional and\/or behavioural improvement or stability. While patients with signs of cognitive improvement could be found across the scale from \u2018very much improved\u2019 to \u2018minimally worse\u2019, patients with functional improvement were rated as having improved or not having changed. Cognitive declines in several domains or any cognitive decline seen with functional declines were the chief drivers of worsening ratings. The CIBIC-Plus notes have potential value in identifying reproducible patterns of clinically relevant treatment effects provided that data are consistent and specific, and that seemingly contradictory information is carefully explored. Clinicians appear to be skeptical of cognitive changes not supported by like changes in function or behaviour.<\/jats:p>","DOI":"10.1159\/000066673","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T21:05:40Z","timestamp":1050440740000},"page":"26-33","source":"Crossref","is-referenced-by-count":11,"title":["Patterns of Clinically Detectable Treatment Effects with Galantamine: A Qualitative Analysis"],"prefix":"10.1159","volume":"15","author":[{"given":"Christine","family":"Joffres","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romola S.","family":"Bucks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy","family":"Haworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gordon K.","family":"Wilcock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Rockwood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,12,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-200007000-00010"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000054761"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/gps.496"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.321.7274.1445"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/66673","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/66673","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:18:40Z","timestamp":1745464720000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000066673"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12,5]]},"references-count":4,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2002,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000066673","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"type":"print","value":"1420-8008"},{"type":"electronic","value":"1421-9824"}],"subject":[],"published":{"date-parts":[[2002,12,5]]}}}