{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,13]],"date-time":"2025-06-13T09:25:01Z","timestamp":1749806701571,"version":"3.40.4"},"reference-count":12,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2002,12,16]],"date-time":"2002-12-16T00:00:00Z","timestamp":1039996800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,12,16]],"date-time":"2002-12-16T00:00:00Z","timestamp":1039996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Psychother Psychosom"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Many short-term trials suggested that the combination of psychotherapy with medication might be more effective than either treatment alone. However, only few studies examined the long-term effectiveness of this combination. &lt;i&gt;Methods:&lt;\/i&gt; A private practice sample of consecutive patients with DSM-III-R panic disorder with agoraphobia who achieved remission after drug treatment with or without concurrent cognitive-behavioural psychotherapy were followed up. Patients were assessed before treatment, after treatment and at each follow-up contact with the Marks-Sheehan Phobia Scale, the Hamilton Anxiety Rating Scale, and the Hamilton Depression Rating Scale. Kaplan-Meier survival analysis was performed on the time to panic disorder relapse. Cox regression analysis was used to control for the possible confounding effect of factors other than treatment. &lt;i&gt;Results:&lt;\/i&gt; Of patients who received medication alone (n = 32), 25 (78.1%) relapsed, prevalently (65.6%) during the first year. The estimated mean survival time was 12 months (95% CI 7\u201317). Of patients who received integrated treatment (n = 21), only 3 (14.3%) relapsed. The estimated mean survival time was 65 months (95% CI 44\u201386). Treatment was the only variable associated with the occurrence of relapse, with a hazard ratio of 12.6 (95% CI 2.5\u201363.3) for patients who received only medication. &lt;i&gt;Conclusions:&lt;\/i&gt; Some methodological limitations, such as treatment allocation by preference, suggest caution in the interpretation of our results. However, the long-term therapeutic advantage of integrated treatment over medication alone was large and independent from known prognostic factors. The long-term effectiveness of integrated treatment should be tested with a randomised controlled trial.<\/jats:p>","DOI":"10.1159\/000067186","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T21:05:40Z","timestamp":1050440740000},"page":"34-42","source":"Crossref","is-referenced-by-count":18,"title":["Increased Probability of Remaining in Remission from Panic Disorder with Agoraphobia after Drug Treatment in Patients Who Received Concurrent Cognitive-Behavioural Therapy: A Follow-Up Study"],"prefix":"10.1159","volume":"72","author":[{"given":"Massimo","family":"Biondi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Picardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2002,12,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.5.669"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0278-5846(93)90005-D"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097\/00005053-199708000-00006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0005-7967(93)90036-T"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1017\/S0033291701003592"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-11221"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000056279"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1037\/\/0022-006X.67.1.151"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000049350"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159\/000056283"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159\/000012390"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159\/000012402"}],"container-title":["Psychotherapy and Psychosomatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/67186","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/67186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:22:59Z","timestamp":1745464979000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000067186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12,16]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2003,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000067186","archive":["Portico"],"relation":{},"ISSN":["0033-3190","1423-0348"],"issn-type":[{"type":"print","value":"0033-3190"},{"type":"electronic","value":"1423-0348"}],"subject":[],"published":{"date-parts":[[2002,12,16]]}}}