{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T11:37:48Z","timestamp":1772192268043,"version":"3.50.1"},"reference-count":16,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>Visual-spatial working memory (WM) impairment is frequently associated with the early stage of Parkinson\u2019s disease (PD). The aim of this study was to evaluate the performance of a group of PD patients in visual-spatial and visual-object WM tasks and to investigate the effect of administering the dopaminergic agonist apomorphine (experiment 1) or the dopamine precursor &lt;i&gt;L&lt;\/i&gt;-dopa (experiment 2) on the performance of tests assessing these functions. To study WM processes, the PD patients and age-matched normal controls were given an n-back task paradigm. In both experiments, the PD patients were submitted to two evaluations: one after a 12-hour therapy washout and the other 15 min after a subcutaneous infusion of apomorphine (average 0.04 mg\/kg) or 20\/30 min after &lt;i&gt;L&lt;\/i&gt;-dopa intake (200 mg p.o.). The apomorphine infusion had a worsening effect on reaction times in both visual-spatial and visual-object WM tasks, but it did not influence performance accuracy. Instead, &lt;i&gt;L&lt;\/i&gt;-dopa administration had a ameliorative effect on accuracy and reaction times in both visual-spatial and visual-object tasks. These results highlight the role of dopamine in the modulation of the WM function in PD patients.<\/jats:p>","DOI":"10.1159\/000067968","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T21:05:40Z","timestamp":1050440740000},"page":"55-66","source":"Crossref","is-referenced-by-count":92,"title":["Dopaminergic Modulation of Visual-Spatial Working Memory in Parkinson\u2019s Disease"],"prefix":"10.1159","volume":"15","author":[{"given":"Alberto","family":"Costa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Peppe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grazia","family":"Dell\u2019Agnello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni Augusto","family":"Carlesimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luigi","family":"Murri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ubaldo","family":"Bonuccelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Caltagirone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,1,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3932(90)90137-D"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1037\/\/0894-4105.9.1.126"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0168-0102(94)90063-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1126\/science.283.5408.1657"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/376572a0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3956(75)90026-6"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.13.7721"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1037\/\/0894-4105.11.2.171"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.011524298"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1037\/\/0894-4105.14.2.247"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200007)15:4<613::AID-MDS1005>3.0.CO;2-F"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s002130051148"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.4.470"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(00)00028-2"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050091"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(99)00037-8"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/67968","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/67968","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:29:41Z","timestamp":1745465381000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000067968"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":16,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2003,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000067968","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}