{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T19:18:13Z","timestamp":1757704693292,"version":"3.40.4"},"reference-count":7,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2003]]},"abstract":"<i>Background\/Aims:<\/i> There is evidence that hereditary predisposition contributes to the development of diabetic nephropathy and hypertension. Polymorphisms in the genes for bradykinin receptors (B<sub>1<\/sub>R and B<sub>2<\/sub>R) were found to be associated with decreased risk of the development of end-stage renal disease. This study examines whether B<sub>1<\/sub>R G<sup>\u2013699<\/sup>C and B<sub>2<\/sub>R C<sup>181<\/sup>T polymorphisms are associated with microalbuminuria or overt nephropathy, or blood pressure variation in type 2 diabetic subjects. <i>Methods:<\/i> B<sub>1<\/sub>R and B<sub>2<\/sub>R polymorphisms were determined in 153 type 2 diabetic patients with microalbuminuria, 132 with overt nephropathy (macroalbuminuria or chronic renal failure), and 161 patients with normoalbuminuria despite diabetes duration longer than 10 years. <i>Results: <\/i>Distributions of the examined polymorphisms did not differ between patients with microalbuminuria or overt nephropathy, compared to normoalbuminuric control subjects. Patients carrying the B<sub>2<\/sub>R T allele had lower DBP, compared with non-carriers: 83.6 \u00b1 12.0 vs. 87.4 \u00b1 12.1 mm Hg, p < 0.05. Among patients not receiving ACEI, both SBP and DBP was significantly lower in B<sub>2<\/sub>R T allele carriers, compared to non-carriers (137.2 \u00b1 20.3 vs. 146.5 \u00b1 21.7 mm Hg, and 80.3 \u00b1 11.9 vs. 85.8 \u00b1 11.6\u00a0mm Hg, p < 0.05). <i>Conclusions:<\/i> Examined polymorphisms are not associated with the increased risk of incipient or overt nephropathy in type 2 diabetic patients. B<sub>2<\/sub>R C<sup>181<\/sup>T polymorphism may contribute to blood pressure variation in these subjects.<\/jats:p>","DOI":"10.1159\/000068035","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T21:05:40Z","timestamp":1050440740000},"page":"112-116","source":"Crossref","is-referenced-by-count":11,"title":["Polymorphic Genes for Kinin Receptors, Nephropathy and Blood Pressure in Type 2 Diabetic Patients"],"prefix":"10.1159","volume":"23","author":[{"given":"Marcin J.","family":"Zychma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janusz","family":"Gumprecht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanda","family":"Trautsolt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Szydlowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wladyslaw","family":"Grzeszczak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,1,17]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1056\/NEJM199810293391804"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1159\/000013605"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1016\/0162-3109(96)00082-3"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1253\/jcj.63.759"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1016\/S0895-7061(00)01215-2"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1007\/s004390050117"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1002\/(SICI)1096-8628(19981228)80:5<521::AID-AJMG17>3.0.CO;2-2"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/68035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/68035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:29:56Z","timestamp":1745465396000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000068035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":7,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2003,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000068035","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"type":"print","value":"0250-8095"},{"type":"electronic","value":"1421-9670"}],"subject":[],"published":{"date-parts":[[2003]]}}}