{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T16:23:02Z","timestamp":1773246182065,"version":"3.50.1"},"reference-count":6,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Objective: &lt;\/i&gt;To analyze the secretion of the insulin precursor proinsulin in patients with \u03b2-thalassemia and its possible relation to iron overload. &lt;i&gt;Methods: &lt;\/i&gt;We assessed fasting proinsulin, insulin, C-peptide and glucose levels from 34 patients with \u03b2-thalassemia and 33 healthy controls. The correlation to age, body mass index, hepatic iron concentration, serum ferritin and serum AST was analyzed. &lt;i&gt;Results:&lt;\/i&gt; Fasting proinsulin (p &lt; 0.002) and proinsulin-to-insulin ratio (p &lt; 0.02) were significantly increased in patients with thalassemia irrespective of the degree of glucose tolerance. They correlated positively to serum ferritin, liver iron, patient age and serum AST (all p &lt; 0.05). &lt;i&gt;Conclusions:&lt;\/i&gt; Disproportionately elevated proinsulin levels in thalassemic patients indicate early \u03b2-cell dysfunction due to siderosis. An additional biological significance of hyperproinsulinemia and its possible ability to predict long-term iron toxicity in these patients remain to be clarified.<\/jats:p>","DOI":"10.1159\/000068572","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T21:05:40Z","timestamp":1050440740000},"page":"73-78","source":"Crossref","is-referenced-by-count":10,"title":["Disproportionately Elevated Fasting Proinsulin Levels in Normoglycemic Patients with Thalassemia major Are Correlated to the Degree of Iron Overload"],"prefix":"10.1159","volume":"59","author":[{"given":"Holger","family":"Cario","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhard W.","family":"Holl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus-Michael","family":"Debatin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Kohne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,2,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.77.2.478"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051271"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.79.6.1570"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.2.604"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007\/s002770050002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.79.6.1806"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/68572","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/68572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:36:01Z","timestamp":1745465761000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000068572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":6,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2003,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000068572","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}