{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:48:31Z","timestamp":1761580111615,"version":"3.40.4"},"reference-count":7,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Neurosci"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>We tested the response of stress-activated mitogen-activated protein kinases (MAPKs) \u2013 p38 MAPK and c-JUN NH&lt;sub&gt;2&lt;\/sub&gt;-terminal kinase (JNK) \u2013 following hypoxia-ischemia (H-I) induced by unilateral carotid artery ligation and hypoxia (8% O&lt;sub&gt;2&lt;\/sub&gt; and 92% N&lt;sub&gt;2&lt;\/sub&gt;) for 2.5 h in postnatal-day-7 rats. Phosphorylation of p38 MAPK increased in the hippocampus and cortex immediately following H-I and returned to a basal level 6 h later. In contrast to p38 MAPK, phosphorylation of JNK decreased in the hippocampus and cortex immediately following H-I. Intracerebroventricular administration of two different p38 MAPK inhibitors prior to H-I significantly protected the neonatal brain from H-I injury. Interestingly, p38 MAPK inhibitors did not attenuate caspase-3 activation 24 h after H-I. Thus, these data suggest that p38 MAPKs contribute to the rapid, early component of brain injury following neonatal H-I.<\/jats:p>","DOI":"10.1159\/000069046","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T12:11:24Z","timestamp":1050408684000},"page":"405-410","source":"Crossref","is-referenced-by-count":21,"title":["Evidence that p38 Mitogen-Activated Protein Kinase Contributes to Neonatal Hypoxic-Ischemic Brain Injury"],"prefix":"10.1159","volume":"24","author":[{"given":"Byung","family":"Hee Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjeong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M.","family":"Holtzman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,3,21]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1074\/jbc.M007807200"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1126\/science.286.5443.1358"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1097\/00004647-200007000-00008"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1097\/00004647-200206000-00001"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1074\/jbc.272.30.18518"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1074\/jbc.272.33.20490"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1016\/S0301-0082(99)00042-8"}],"container-title":["Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/69046","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/69046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:41:24Z","timestamp":1745466084000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000069046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":7,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2003,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000069046","archive":["Portico"],"relation":{},"ISSN":["0378-5866","1421-9859"],"issn-type":[{"type":"print","value":"0378-5866"},{"type":"electronic","value":"1421-9859"}],"subject":[],"published":{"date-parts":[[2002]]}}}