{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T20:46:57Z","timestamp":1762807617652,"version":"3.40.4"},"reference-count":4,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dev Neurosci"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>Damage after a hypoxic-ischemic (HI) insult is both region and cell population specific [Johnston, 1998]. This observation is critically evident in, and important to, the pathogenesis of the insult in the immature central nervous system. In the term human neonate, damage to the deep grey nuclei is seen using magnetic resonance imaging (MRI) modalities such as diffusion tensor imaging, MR spectroscopy, and structural MRI [Barkovich et al., 1999, 2001]. The loss of T&lt;sub&gt;2&lt;\/sub&gt;-weighted signal in the posterior limb of the internal capsule has become the gold standard in predicting neurological injury with MRI [Rutherford et al., 1995]. Early spectroscopic changes of a variety of metabolites like lactate, N-acetyl aspartate, choline and creatine using single-voxel techniques, coupled with the presence of clinical neonatal seizures can aid in the accurate prediction of neurodevelopmental outcome after HI in the term newborn [Miller et al., 2002]. Neonatal physiological profiles in the first 24 h of life also contribute to a better prediction of outcome in the mildly and severely affected newborn [Newton et al., 2001].<\/jats:p>","DOI":"10.1159\/000069048","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T12:11:24Z","timestamp":1050408684000},"page":"349-351","source":"Crossref","is-referenced-by-count":16,"title":["Timing Is Everything \u2013 Delaying Therapy for Delayed Cell Death"],"prefix":"10.1159","volume":"24","author":[{"given":"Donna M.","family":"Ferriero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,3,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200009)48:3<285::AID-ANA2>3.3.CO;2-#"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159\/000046143"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000046140"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0173(98)00018-6"}],"container-title":["Developmental Neuroscience"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/69048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/69048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:41:26Z","timestamp":1745466086000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000069048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":4,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2003,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000069048","archive":["Portico"],"relation":{},"ISSN":["0378-5866","1421-9859"],"issn-type":[{"type":"print","value":"0378-5866"},{"type":"electronic","value":"1421-9859"}],"subject":[],"published":{"date-parts":[[2002]]}}}