{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T22:50:13Z","timestamp":1774565413756,"version":"3.50.1"},"reference-count":10,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>We used a prematurely born rat\/hyperoxia model of bronchopulmonary dysplasia (BPD) to test whether keratinocyte growth factor (KGF) treatment would protect against the development of several serious (cardio-)pulmonary complications of early life exposure to hyperoxia. KGF significantly protected against hyperoxic lethality (13-day survival rate = 50\/64 (78%) for the O&lt;sub&gt;2&lt;\/sub&gt;-KGF vs. 29\/66 (44%) for the O&lt;sub&gt;2&lt;\/sub&gt;-saline group, p &lt; 0.001). Although KGF failed to protect against hyperoxic inhibition of normal postnatal alveoli formation and early pulmonary fibrosis, KGF consistently had a significant protective\/preventive effect against the development of pulmonary hypertension during hyperoxia as reflected in comparative right ventricular hypertrophy: mean increase = +35% above normal for the O&lt;sub&gt;2&lt;\/sub&gt;-saline group vs. +3% for the O&lt;sub&gt;2&lt;\/sub&gt;-KGF premature rat group (p &lt; 0.01).<\/jats:p>","DOI":"10.1159\/000069480","type":"journal-article","created":{"date-parts":[[2003,5,12]],"date-time":"2003-05-12T15:51:21Z","timestamp":1052754681000},"page":"263-272","source":"Crossref","is-referenced-by-count":28,"title":["Protective Effect of Keratinocyte Growth Factor against Lung Abnormalities Associated with Hyperoxia in Prematurely Born Rats"],"prefix":"10.1159","volume":"83","author":[{"given":"Lee","family":"Frank","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,5,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(98)90280-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(70)80488-4"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.62.1.825"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4652(199912)181:3<424::AID-JCP6>3.0.CO;2-Z"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199606000-00009"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200112-134BC"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0049com"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.21.12607"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.16.11858"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1378\/chest.120.1_suppl.S27"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/69480","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/69480","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:45:44Z","timestamp":1745466344000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000069480"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":10,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2003,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000069480","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}