{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:02:50Z","timestamp":1789009370998,"version":"build-2803163510"},"reference-count":3,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Public Health Genomics"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To compare the efficacy of routine haematological tests and molecular analysis in the diagnosis of double heterozygous \u03b1- and \u03b2-thalassaemia. &lt;i&gt;Methods:&lt;\/i&gt; Screening was carried out in extended family members from 125 families registered in the National Thalassaemia Registry, known to have both \u03b1- and \u03b2-thalassaemia carriers. &lt;i&gt;Results:&lt;\/i&gt; Eighty-three individuals from 59 families were identified to be double heterozygous for \u03b1- and \u03b2-thalassaemia only upon molecular analyses. Among 40 married individuals, 1 was at 25% risk for having \u03b2-thalassaemia major children and 6 for having Bart\u2019s hydrops pregnancies. &lt;i&gt;Conclusion:&lt;\/i&gt; Molecular analysis must be used for the accurate diagnosis of double heterozygous \u03b1- and \u03b2-thalassaemia for proper risk ascertainment, especially in regions with a high prevalence of both types of thalassaemia.<\/jats:p>","DOI":"10.1159\/000069539","type":"journal-article","created":{"date-parts":[[2003,4,15]],"date-time":"2003-04-15T09:24:25Z","timestamp":1050398665000},"page":"14-21","source":"Crossref","is-referenced-by-count":9,"title":["The Simultaneous Presence of \u03b1- and \u03b2-Thalassaemia Alleles: A Pitfall of Thalassaemia Screening"],"prefix":"10.1159","volume":"6","author":[{"given":"H.Y.","family":"Law","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.K.L.","family":"Chee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.P.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.S.L.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2003,4,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.med.45.1.211"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02073-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0223(199708)17:8<733::AID-PD141>3.0.CO;2-F"}],"container-title":["Public Health Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/69539","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/69539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:46:07Z","timestamp":1745466367000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000069539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":3,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2003,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000069539","archive":["Portico"],"relation":{},"ISSN":["1662-4246","1662-8063"],"issn-type":[{"value":"1662-4246","type":"print"},{"value":"1662-8063","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}