{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:36:05Z","timestamp":1791423365327,"version":"4.3.3"},"reference-count":2,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>We studied the effect of fosfomycin (FOM) on the intracellular growth of two different facultative intracellular bacteria, &lt;i&gt;Salmonella enterica&lt;\/i&gt; serovar Typhimurium and &lt;i&gt;Listeria monocytogenes&lt;\/i&gt;, in an enterocyte-like cell line, Caco-2. These bacteria replicate in different compartments within the host cells; &lt;i&gt;Salmonella&lt;\/i&gt; serovar Typhimurium grow inside phagosomes, whereas &lt;i&gt;L. monocytogenes&lt;\/i&gt; escape the phagosomal environment and multiply in the cytosol of the host cells. At concentrations equal to 0.25 of the MIC and 4 times the MIC, respectively, FOM effectively decreased the number of intracellular &lt;i&gt;Salmonella&lt;\/i&gt; serovar Typhimurium. Although FOM was ineffective at inhibiting the extracellular growth of &lt;i&gt;L.\u00a0monocytogenes&lt;\/i&gt; in vitro, this antibiotic induced a marked reduction in intracellular &lt;i&gt;L. monocytogenes&lt;\/i&gt;, indicating that, comparatively, FOM may be more effectively taken up by &lt;i&gt;L. monocytogene&lt;\/i&gt;s in the intracellular environment.<\/jats:p>","DOI":"10.1159\/000069787","type":"journal-article","created":{"date-parts":[[2003,4,25]],"date-time":"2003-04-25T13:11:41Z","timestamp":1051276301000},"page":"49-55","source":"Crossref","is-referenced-by-count":7,"title":["Intracellular Activity of Fosfomycin against Two Distinct Enteropathogenic Bacteria, &lt;i&gt;Salmonella enterica&lt;\/i&gt; and &lt;i&gt;Listeria monocytogenes,&lt;\/i&gt; Alive inside Host Cells"],"prefix":"10.1159","volume":"49","author":[{"given":"Nobuhiko","family":"Okada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miki","family":"Nishio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Danbara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2003,5,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1097(88)90313-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-1097(93)90134-N"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/69787","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/69787","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:14:00Z","timestamp":1745464440000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000069787"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":2,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2003,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000069787","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}