{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:30:23Z","timestamp":1760121023445,"version":"3.40.4"},"reference-count":15,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2002,1,1]],"date-time":"2002-01-01T00:00:00Z","timestamp":1009843200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroimmunomodulation"],"published-print":{"date-parts":[[2002]]},"abstract":"<jats:p>Serum cortisol levels were evaluated in mice following intravenous administration of purified mycobacterial glycolipid trehalose 6,6\u2032-dimycolate (TDM). C57BL\/6 mice develop lung granulomas in response to TDM, while A\/J mice are deficient in this process. Administration of TDM to C57BL\/6 mice led to a rapid reduction in serum cortisol, concurrent with initiation of the granulomatous response and cytokine and chemokine mRNA induction. Cortisol levels were lowest on day 5 after TDM administration, but there was significant production of IL-6, TNF-\u03b1 and IL-1\u03b2 messages. Granuloma formation and full immune responsiveness to TDM were only apparent upon a sufficient decrease in levels of systemic cortisol. Treatment of the C57BL\/6 mice with hydrocortisone abolished inflammatory responses. Histologically nonresponding A\/J mice exhibited higher constitutive serum cortisol and demonstrated different kinetics of cortisol reduction upon administration of TDM. A\/J mice demonstrated hyperplastic morphology in the suprarenal gland with a high degree of vacuolization in the medullary region and activation of cells in the zona fasciculata and zona reticularis. The A\/J mice were dysregulated with respect to cytokine responses thought to be necessary during granuloma formation. The high constitutive serum cortisol in the A\/J mice may therefore contribute to pulmonary immunoresponsiveness and the establishment of an environment counterproductive to the initiation of granulomatous responses. The identification of a mycobacterial glycolipid able to influence serum cortisol levels is unique and is discussed in relation to immunopathology during tuberculosis disease.<\/jats:p>","DOI":"10.1159\/000069971","type":"journal-article","created":{"date-parts":[[2003,5,28]],"date-time":"2003-05-28T07:40:46Z","timestamp":1054107646000},"page":"270-282","source":"Crossref","is-referenced-by-count":11,"title":["Mycobacterial Glycolipid Cord Factor Trehalose 6,6\u2019-Dimycolate Causes a Decrease in Serum Cortisol during the Granulomatous Response"],"prefix":"10.1159","volume":"10","author":[{"given":"Jeffrey K.","family":"Actor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Indrigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher M.","family":"Beachdel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Olsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Wells","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert L.","family":"Hunter Jr.","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amitava","family":"Dasgupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,5,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-2478(94)00161-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1089\/107999099313136"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(200002)190:2<211::AID-PATH530>3.0.CO;2-3"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4800(87)90065-7"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1089\/10799900050151067"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1089\/107999001317205222"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1086\/324664"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2825(1996)10:6<423::AID-JCLA19>3.0.CO;2-Z"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(93)90346-9"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.44.127"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.50.1.259"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1084\/jem.177.2.523"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.2.810-815.2001"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.9.5305-5312.2001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/1074-7613(95)90001-2"}],"container-title":["Neuroimmunomodulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/69971","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/69971","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:16:26Z","timestamp":1745464586000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000069971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002]]},"references-count":15,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2003,5,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000069971","archive":["Portico"],"relation":{},"ISSN":["1021-7401","1423-0216"],"issn-type":[{"type":"print","value":"1021-7401"},{"type":"electronic","value":"1423-0216"}],"subject":[],"published":{"date-parts":[[2002]]}}}