{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:09:27Z","timestamp":1745554167905,"version":"3.40.4"},"reference-count":5,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Purpose:&lt;\/i&gt; To determine whether irsogladine inhibits experimental choroidal neovascularization (CNV) induced by laser photocoagulation in pigmented rats. &lt;i&gt;Methods:&lt;\/i&gt; Focal laser photocoagulation (argon green 50 mW, 0.04\u00a0s, 200 \u00b5m) was applied to the retinochoroid of normal Brown Norway rats. Oral administration of irsogladine (5\u00a0mg\/kg\/day or 50 mg\/kg\/day) was started 1 week before and continued for 2 weeks after laser photocoagulation. Choroidal vascular casts were made 2 weeks after laser photocoagulation and were examined with a scanning electron microscope (SEM). CNV formation was classified according to three grades and evaluated. &lt;i&gt;Results:&lt;\/i&gt; Laser-induced CNV formation was significantly reduced in rats given 5 mg\/kg\/day (p &lt; 0.01) or 50 mg\/kg\/day of irsogladine (p &lt; 0.001). Administration of 50 mg\/kg\/day of irsogladine was more effective in preventing CNV formation than 5 mg\/kg\/day (p &lt; 0.001). The development of the vascular bud was especially inhibited by 50 mg\/kg\/day of irsogladine (p &lt; 0.001). CNVs in rats treated with 50 mg\/kg\/day of irsogladine looked less well developed than those in controls. There was no significant side effect of irsogladine. &lt;i&gt;Conclusions:&lt;\/i&gt; Irsogladine inhibits the development of experimental CNV induced by photocoagulation in pigmented rats.<\/jats:p>","DOI":"10.1159\/000070048","type":"journal-article","created":{"date-parts":[[2003,4,25]],"date-time":"2003-04-25T13:11:41Z","timestamp":1051276301000},"page":"137-142","source":"Crossref","is-referenced-by-count":2,"title":["Inhibition of Experimental Choroidal Neovascularization by Irsogladine, an Anti-Gastric Ulcer Agent"],"prefix":"10.1159","volume":"35","author":[{"given":"Akiko Mera","family":"Kuroki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kitaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsugio","family":"Amemiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,4,25]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1016\/S0021-5155(97)00058-0"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1006\/bbrc.1995.1365"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1016\/0014-5793(93)81558-H"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1076\/ceyr.23.4.240.5450"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1006\/excr.1993.1028"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/70048","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/70048","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:16:53Z","timestamp":1745464613000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000070048"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":5,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2003,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000070048","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"type":"print","value":"0030-3747"},{"type":"electronic","value":"1423-0259"}],"subject":[],"published":{"date-parts":[[2003]]}}}