{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:31:38Z","timestamp":1759336298593,"version":"3.40.4"},"reference-count":6,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; Evidence of anti-thyroid-stimulating hormone (TSH) antibody in Graves\u2019 serum has been reported. We found that extremely high Graves\u2019 anti-TSH antibodies neutralized other Graves\u2019 thyroid-stimulating antibody (TSAb) activity. &lt;i&gt;Method:&lt;\/i&gt; TSAb-IgG was affinity-purified by Sepharose-bound Graves\u2019 anti-TSH antibody (extremely high). &lt;i&gt;Result:&lt;\/i&gt; The thyroid-stimulating activity in affinity-purified TSAb-IgG increased about 4\u20135 times compared to that before purification. TSH-binding inhibitory immunoglobulin (TBII) activity in affinity-purified TSAb-IgG also increased using TSH receptor-coated tube assay. A similar increase of thyroid-stimulating activity accompanied with TBII activity was also observed in affinity-purified TSAb-IgG-F(ab\u2032)&lt;sub&gt;2&lt;\/sub&gt;. &lt;i&gt;Conclusion:&lt;\/i&gt; This suggests the possibility that either TSAb may be an anti-idiotypic antibody against anti-TSH antibody or anti-TSH antibody may be an anti-idiotypic antibody against anti-TSH receptor antibody.<\/jats:p>","DOI":"10.1159\/000070221","type":"journal-article","created":{"date-parts":[[2003,4,25]],"date-time":"2003-04-25T13:11:41Z","timestamp":1051276301000},"page":"222-228","source":"Crossref","is-referenced-by-count":1,"title":["Interaction of Thyroid-Stimulating Antibody with Graves\u2019 Thyroid-Stimulating Hormone-Binding Antibody"],"prefix":"10.1159","volume":"59","author":[{"given":"Y.","family":"Ochi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Kajita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Hamazu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,5,8]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1089\/10507250252949414"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1089\/105072501300176408"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/0896-8411(92)90153-H"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0024-3205(83)90175-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.9.4254"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1089\/105072502753522347"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/70221","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/70221","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:18:42Z","timestamp":1745464722000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000070221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":6,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2003,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000070221","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2003]]}}}