{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T19:14:13Z","timestamp":1779909253421,"version":"3.53.1"},"reference-count":8,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Death with a functioning graft (DWF) has been reported as a major cause of graft loss after renal transplantation. It has been reported to occur in 9\u201330%. &lt;i&gt;Methods:&lt;\/i&gt; From March 1976 to January 2002, a total of 1,400 living donor renal transplants were performed in our center. Out of 257 reported deaths among our patients, 131 recipients died with functioning grafts after a mean period of 53.4 \u00b1 53.2 months. &lt;i&gt;Results:&lt;\/i&gt; DWF patients account for 27% of all graft losses in our series. The mean age was 34.9 + 10.6 (range 8\u201362 years), 98 of them were male and 33 were female. The original kidney disease was GN in 9, PN in 24, PCK in 5 and nephrosclerosis in 8 patients. Acute rejection episodes were diagnosed in 84 patients (63.1). The post-transplant complications encountered were hypertension in 78 patients (59.5%), diabetes mellitus in 30 patients (22.9%), medical infections in 68 (51.5%), hepatic complications in 30 (22.9%) and malignancy in 17 patients (13%). The main causes of death in these patients were infections in 46 (35.6%), cardiovascular in 23 (17.6%), liver cell failure in 15 patients (11.4%) and malignancy in 8 (6.1%). The mean serum creatinine was 2 \u00b1 0.6 mg\/dl at last follow-up before death. &lt;i&gt;Conclusion:&lt;\/i&gt; We conclude that the relatively higher mortality in renal transplantation is, in part, due to co-morbid medical illness, pre-transplant dialysis treatment, and factors uniquely related to transplantation, including immunosuppression and other drug effects. DWF must be in consideration when calculating graft survival.<\/jats:p>","DOI":"10.1159\/000070864","type":"journal-article","created":{"date-parts":[[2003,4,25]],"date-time":"2003-04-25T13:11:41Z","timestamp":1051276301000},"page":"186-193","source":"Crossref","is-referenced-by-count":23,"title":["Death with Functioning Graft in Living Donor Kidney Transplantation: Analysis of Risk Factors"],"prefix":"10.1159","volume":"23","author":[{"given":"Amgad E.","family":"El-Agroudy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Bakr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed B.","family":"Shehab El-Dein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Ghoneim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2003,5,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(00)01352-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(97)01041-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200003023420901"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199605270-00012"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(01)02472-1"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-1345(98)00948-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000013523"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-0012.2000.14040802.x"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/70864","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/70864","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:24:47Z","timestamp":1745465087000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000070864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":8,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2003,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000070864","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}