{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:28:58Z","timestamp":1789194538651,"version":"build-2803163510"},"reference-count":10,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Heparin-binding epidermal-growth-factor-like growth factor (HB-EGF) has proved to be a mitogen of keratinocytes, which may be involved in the pathogenesis of inflammatory diseases, but its mechanism in psoriasis remains unknown. &lt;i&gt;Objective:&lt;\/i&gt; To investigate the alteration of HB-EGF in the epidermis of active psoriasis vulgaris. &lt;i&gt;Methods:&lt;\/i&gt; The expression of HB-EGF in normal skin tissues, uninvolved tissues and psoriatic lesions was detected by in situ hybridization and immunohistochemistry. &lt;i&gt;Results:&lt;\/i&gt; HB-EGF mRNA and protein were located in the basal layer of normal epidermis (10\/10, 100.00%), with nearly no expression in the suprabasal layers (1\/10, 10.00%); the expression of HB-EGF was located not only in the basal layer (21\/21, 100.00%), but was also seen as focal overexpression in the suprabasal layers of uninvolved epidermis (20\/21, 95.24%) and the marginal part of psoriatic lesions (18\/21, 85.71%), while nearly no expression of HB-EGF was found in the central part of psoriatic lesions (1\/21, 4.76%). &lt;i&gt;Conclusion:&lt;\/i&gt; HB-EGF may play an important role in the early pathogenesis of psoriasis.<\/jats:p>","DOI":"10.1159\/000070936","type":"journal-article","created":{"date-parts":[[2003,7,11]],"date-time":"2003-07-11T08:22:02Z","timestamp":1057911722000},"page":"22-27","source":"Crossref","is-referenced-by-count":15,"title":["Alteration and Significance of Heparin-Binding Epidermal-Growth-Factor-Like Growth Factor in Psoriatic Epidermis"],"prefix":"10.1159","volume":"207","author":[{"given":"Yan","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenhui","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengshun","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guorong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2003,7,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/18.6.1539"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.6.1268"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.128.5.929"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.36.25906"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12318465"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2000.106515"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(94)E0124-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.1999.1068"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1021\/jm010349c"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/00005392-200012000-00074"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/70936","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/70936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:25:56Z","timestamp":1745465156000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000070936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2003,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000070936","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}