{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T13:16:54Z","timestamp":1772889414251,"version":"3.50.1"},"reference-count":10,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>This study was performed to investigate whether or not endogenous histamine can protect seizure development of pentylenetetrazole (PTZ)-induced kindling in rats. An intracerebroventricular (i.c.v.) injection with clobenpropit (5 and 10 \u00b5g), a representative H&lt;sub&gt;3&lt;\/sub&gt;-antagonist, significantly prolonged the onset of kindling and inhibited the seizure stages in a dose-dependent manner. Its action was significantly reversed by both immepip (2 \u00b5g, i.c.v.), an H&lt;sub&gt;3&lt;\/sub&gt;-agonist, and \u03b1-fluoromethylhistidine (\u03b1-FMH, 10\u00a0\u00b5g, i.c.v.), a selective histidine decarboxylase inhibitor. \u03b1-FMH (20 \u00b5g, i.c.v.) and pyrilamine (1 and 5 mg\/kg i.p.), a classical H&lt;sub&gt;1&lt;\/sub&gt;-antagonist, markedly augmented the severity of seizure development of PTZ-induced kindling. Therefore, these results indicate that brain endogenous histamine plays a certain protective role on seizure development of PTZ-induced kindling in rats, and that its protective roles are mediated by H&lt;sub&gt;1&lt;\/sub&gt;-receptors.<\/jats:p>","DOI":"10.1159\/000071263","type":"journal-article","created":{"date-parts":[[2003,7,29]],"date-time":"2003-07-29T09:18:09Z","timestamp":1059470289000},"page":"27-32","source":"Crossref","is-referenced-by-count":35,"title":["Effects of Endogenous Histamine on Seizure Development of Pentylenetetrazole-Induced Kindling in Rats"],"prefix":"10.1159","volume":"69","author":[{"given":"Li-San","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Wen","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei-Wei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Er-Qing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiko","family":"Yanai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,8,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(99)00128-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(98)00048-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(00)03041-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(91)90062-K"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0920-1211(91)90003-X"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199406093302307"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(86)90029-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(84)90811-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(93)90717-V"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(94)90005-1"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/71263","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/71263","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:29:45Z","timestamp":1745465385000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000071263"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2003,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000071263","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}