{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T02:09:19Z","timestamp":1773886159889,"version":"3.50.1"},"reference-count":13,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2004,11,17]],"date-time":"2004-11-17T00:00:00Z","timestamp":1100649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2004,11,17]],"date-time":"2004-11-17T00:00:00Z","timestamp":1100649600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<i>Background\/Aims:<\/i> We investigated whether urinary podocytes are present in septic patients with methicillin-resistant <i>Staphylococcus aureus<\/i> (MRSA)-associated glomerulonephritis and whether polymyxin B-immobilized fiber (PMX-F) treatment affects proteinuria and urinary podocyte excretion in these patients. <i>Methods:<\/i> Twenty septic patients with MRSA-associated glomerulonephritis (mean age: 63.7 years) and 80 septic patients whose MRSA infection was not followed by glomerulonephritis (mean age: 60.5 years) were included in this study. All septic patients were treated with fosfomycin sodium, \u03b2-lactams, arbekacin sulfate, and teicoplanin, or a combination of these. Twenty septic patients with MRSA-associated glomerulonephritis were randomly assigned to one of two treatments: PMX-F treatment (group A, n = 10) and conventional treatment (group B, n = 10). PMX-F treatment was repeated twice. <i>Results:<\/i> Urinary podocytes and urinary protein excretion were not detected in MRSA septic patients without glomerulonephritis. However, urinary podocytes (1.7 \u00b1 0.6 cells\/ml) and proteinuria (2.6 \u00b1 0.6 g\/d) were detected in the 20 septic patients with MRSA-associated glomerulonephritis. Plasma endotoxin levels were decreased from 13.6 \u00b1 4.6 pg\/ml to 6.6 \u00b1 2.2 pg\/ml (p < 0.05) in group A. Levels in group B, however, showed little difference after treatment. Urinary podocytes were reduced in group A (from 1.8 \u00b1 0.6 cells\/ml to 0.4 \u00b1 0.2 cells\/ml, p < 0.01) as was urinary protein excretion (from 3.0 \u00b1 0.5 g\/d to 0.8 \u00b1 0.4 g\/d, p < 0.01) but urinary podocytes and protein excretion levels showed little difference after treatment in group B. <i>Conclusion:<\/i> PMX-F treatment may be effective in reducing urinary protein and urinary podocyte excretion in septic patients with MRSA-associated glomerulonephritis.<\/jats:p>","DOI":"10.1159\/000071279","type":"journal-article","created":{"date-parts":[[2003,7,11]],"date-time":"2003-07-11T08:22:02Z","timestamp":1057911722000},"page":"c33-c39","source":"Crossref","is-referenced-by-count":18,"title":["Hemoperfusion with Polymyxin B-Immobilized Fiber in Septic Patients with Methicillin-Resistant <i>Staphylococcus aureus<\/i>-Associated Glomerulonephritis"],"prefix":"10.1159","volume":"94","author":[{"given":"Tsukasa","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chifuyu","family":"Ushiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiwori","family":"Osada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruo","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisataka","family":"Shoji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Hara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriaki","family":"Shimada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hikaru","family":"Koide","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2004,11,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.44.2.316-319.2000"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s001340050761"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s000110050442"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-200008000-00009"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000013580"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159\/000013302"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001\/jama.274.12.968"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199812000-00045"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200104000-00015"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-200103000-00006"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199908000-00039"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.154.1.26"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.0550031063.x"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/71279","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/71279","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:29:51Z","timestamp":1745465391000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000071279"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11,17]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2003,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000071279","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,11,17]]}}}