{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T13:23:32Z","timestamp":1778937812273,"version":"3.51.4"},"reference-count":11,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2003]]},"abstract":"<i>Purpose:<\/i> Genetic factors are known to play a role in the etiology of glaucoma. More specifically, the role of the immune system is highly suspected. We evaluated the association between 2 polymorphisms in the interleukin (IL) 1\u03b2 gene (IL-1 promoter 511, IL-1 exon 5) and 1 polymorphism in the IL-1 gene receptor antagonist (IL-1Ra) intron 2 with primary open-angle glaucoma (POAG). <i>Patients and Methods:<\/i> Fifty-eight POAG patients and 105 healthy volunteers were enrolled in this study. Analysis based on polymerase chain reaction was used to resolve the 2 IL-1\u03b2 polymorphisms and the IL-1Ra intron 2 polymorphism. <i>Results:<\/i> There were significant differences in the distribution of the IL-1\u03b2 exon 5 polymorphism between the POAG patients and the control subjects (p < 0.05). The E2 allele of IL-1\u03b2 exon 5 was more frequently found in POAG patients than in healthy patients (odds ratio: 4.224, 95% confidence interval = 1.135\u201315.717). The distributions of the other 2 polymorphisms, IL-1\u03b2 promoter 511 and IL-1Ra intron 2, were not significantly different between the POAG patients and the healthy control group. <i>Conclusions:<\/i> The frequency of the E2 allele of the IL-1\u03b2 exon 5 polymorphism was high in POAG patients. Therefore the E2 allele can be used as a marker to predict or search for the genetic causes of glaucoma in Chinese POAG patients. Furthermore, we have concluded that the other 2 polymorphisms (IL-1 promoter 511 and IL-1Ra) are not helpful in predicting Chinese POAG.<\/jats:p>","DOI":"10.1159\/000071352","type":"journal-article","created":{"date-parts":[[2003,8,18]],"date-time":"2003-08-18T08:23:26Z","timestamp":1061195006000},"page":"358-364","source":"Crossref","is-referenced-by-count":21,"title":["Association of Interleukin 1\u03b2 and Receptor Antagonist Gene Polymorphisms with Primary Open-Angle Glaucoma"],"prefix":"10.1159","volume":"217","author":[{"given":"Hui-Ju","family":"Lin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"San-Chang","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuu-Jen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Chi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffery J.P.","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Der","family":"Hsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,8,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.266.3.369"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200004000-00014"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050127"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199808)28:08<2598::AID-IMMU2598>3.0.CO;2-K"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097\/00003246-199603000-00004"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199906)42:6<1093::AID-ANR5>3.0.CO;2-P"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(90)90005-T"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038\/85446"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-4141(199808)28:08<2598::AID-IMMU2598>3.0.CO;2-K"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12395398"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.86.7.767"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/71352","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/71352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:30:28Z","timestamp":1745465428000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000071352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":11,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2003,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000071352","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}