{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T21:18:56Z","timestamp":1783977536464,"version":"3.55.0"},"reference-count":10,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Recommendations for the use of antenatal antibiotics have been widely implemented in the past few years, notably to prevent group B streptococcal disease or to prolong pregnancy in the case of preterm premature rupture of the membranes. &lt;i&gt;Objectives:&lt;\/i&gt; We designed a retrospective study to assess the potential effects of this increasing use of antibiotics on the incidence and bacteriological profile of early-onset neonatal sepsis (EONS). &lt;i&gt;Methods:&lt;\/i&gt; All neonates referred to our department for suspected EONS from January 1 1995 through December 31 1999 were included. Antenatal antibiotic exposure together with clinical and microbiological data from the neonatal period were gathered and analyzed on a yearly basis. &lt;i&gt;Results:&lt;\/i&gt; Of the 485 newborns who met the inclusion criteria, there were 101 cases of culture-confirmed sepsis; 339 cases of suspected sepsis and 69 cases of confirmed sepsis involved children born in the hospital, among a total of 16,627 live births registered in our center over the study period. The overall incidence of EONS dropped from 6.8 to 0.6\/1,000 births between 1995 and 1999 (p &lt; 0.001), but the rate of group B streptococcal infection decreased much more rapidly than that of non-group B streptococcal infection. We observed a trend towards the emergence of ampicillin-resistant &lt;i&gt;Escherichia coli&lt;\/i&gt; strains, which were isolated in seven cases. Among &lt;i&gt;E.\u00a0coli&lt;\/i&gt; infections, ampicillin resistance was statistically linked with antenatal antibiotic use (p = 0.025). We also delineated several risk factors associated with these infections. &lt;i&gt;Conclusion:&lt;\/i&gt; In our center, antenatal antibiotic treatment was effective in reducing the incidence of EONS, but this benefit may come at the cost of favoring the emergence of ampicillin-resistant organisms causing severe neonatal infections. Antenatal and postnatal antibiotic treatment strategies should take this adverse effect into account.<\/jats:p>","DOI":"10.1159\/000071439","type":"journal-article","created":{"date-parts":[[2003,7,29]],"date-time":"2003-07-29T09:18:09Z","timestamp":1059470289000},"page":"24-30","source":"Crossref","is-referenced-by-count":17,"title":["Effects of Antenatal Antibiotics on the Incidence and Bacteriological Profile of Early-Onset Neonatal Sepsis"],"prefix":"10.1159","volume":"84","author":[{"given":"V.","family":"Laugel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Beladdale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Donato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Escande","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Astruc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Messer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2003,7,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.99.3.489"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.278.12.989"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04233-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200001063420103"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/jama.279.10.748"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-0997(1999)7:4<210::AID-IDOG10>3.0.CO;2-8"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/080352500750044007"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2001.117354"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012657"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04234-3"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/71439","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/71439","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:30:34Z","timestamp":1745465434000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000071439"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2003,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000071439","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}