{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T03:09:56Z","timestamp":1785726596963,"version":"3.56.0"},"reference-count":12,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Background: &lt;\/i&gt;The incidence of Langerhans cell histiocytosis (LCH) is 4\u20135 per million in children with only 30% of this number having an adult onset. While dermatological manifestations occur in as many as 50% of cases, disease limited to the skin is uncommon among reported cases of adult LCH. &lt;i&gt;Objectives and Methods:&lt;\/i&gt; To present 3 new cases of adult LCH and a review of the literature of isolated cutaneous LCH in adults. &lt;i&gt;Results:&lt;\/i&gt; Three adults with scalp, vulvar and generalized LCH lesions had refractory responses to treatment. &lt;i&gt;Conclusions:&lt;\/i&gt; LCH may present with unusual cutaneous manifestations limited to the skin in adults. Optimal treatment has not yet been determined.<\/jats:p>","DOI":"10.1159\/000071786","type":"journal-article","created":{"date-parts":[[2003,8,22]],"date-time":"2003-08-22T08:19:50Z","timestamp":1061540390000},"page":"157-161","source":"Crossref","is-referenced-by-count":49,"title":["Adult Langerhans Cell Histiocytosis Limited to the Skin"],"prefix":"10.1159","volume":"207","author":[{"given":"Asha","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor G.","family":"Prieto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Czelusta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth L.","family":"McClain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeleine","family":"Duvic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2003,8,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199605000-00001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.123.10.1274"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5836"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.127.10.1545"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.122.4.446"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.119.2.157"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s001050050696"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.119.7.553"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.131.6.719"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12494184"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080\/019131299281761"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/adc.82.6.483"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/71786","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/71786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:33:18Z","timestamp":1745465598000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000071786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2003,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000071786","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}