{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T21:15:32Z","timestamp":1790889332760,"version":"4.1.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropsychobiology"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>The human serotonin transporter (5-HTT) gene is an important candidate for the pathogenesis of mood disorders. Associations have been reported between a variable-number tandem-repeat polymorphism in intron 2 of the serotonin transporter gene (5-HTTVNTR) and mood disorders in a number of studies of Western and Chinese populations. However, no such relationships have been determined in other analogous research. To replicate these positive findings in a Chinese population and to determine the association between onset age of bipolar disorder and 5-HTTVNTR, we investigated the prevalence of this polymorphism in an independent Chinese population (83 bipolar disorder patients, 77 major depressive disorder patients and 169 controls), demonstrating no significant association between the 5-HTTVNTR polymorphism and mood disorders or age at onset. Further, no association was demonstrated between this polymorphism and suicidal history in mood disorder patients. These negative findings suggest that 5-HTTVNTR does not play a major role in the pathogenesis of mood disorder in Chinese populations.<\/jats:p>","DOI":"10.1159\/000071821","type":"journal-article","created":{"date-parts":[[2003,7,29]],"date-time":"2003-07-29T09:18:09Z","timestamp":1059470289000},"page":"5-9","source":"Crossref","is-referenced-by-count":24,"title":["Association Study of Serotonin Transporter Gene VNTR Polymorphism and Mood Disorders, Onset Age and Suicide Attempts in a Chinese Sample"],"prefix":"10.1159","volume":"48","author":[{"given":"Feng-Chang","family":"Yen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen-Jee","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheu-Jane","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiunn-Kae","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Jen","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2003,7,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000415"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)90626-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(99)00178-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.26.15251"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.10119"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90993-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980207)81:1<1::AID-AJMG1>3.0.CO;2-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0447.2001.00173.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980207)81:1<58::AID-AJMG11>3.0.CO;2-V"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90079-3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(20000403)96:2<170::AID-AJMG9>3.0.CO;2-1"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1017\/S003329179900882X"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/00041444-200209000-00004"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(98)00677-6"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)90993-9"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1781(91)90084-3"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000541"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990205)88:1<61::AID-AJMG11>3.0.CO;2-K"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2003.02446.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000856"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1781(00)00229-8"}],"container-title":["Neuropsychobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/71821","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/71821","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:33:33Z","timestamp":1745465613000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000071821"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2003,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000071821","archive":["Portico"],"relation":{},"ISSN":["0302-282X","1423-0224"],"issn-type":[{"value":"0302-282X","type":"print"},{"value":"1423-0224","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}