{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:35:18Z","timestamp":1760146518191,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>The effects of postischemic hyperthermia were investigated in the newborn rat brain after hypoxia-ischemia (HI). Seven-day-old rats were subjected to left carotid artery ligation followed by 8% oxygen for 30 min, and divided into a hyperthermia group (rectal temperature at 39\u00b0C for 6 h) and a normothermia group. Hyperthermia resulted in an approximately 5-fold increase in activated caspase-3 24 h after HI when compared with the normothermia group, and gross loss of brain tissue was observed only in the hyperthermia group at 7 and 30 days after HI. Our results show that postischemic hyperthermia exacerbates HI injury in immature brains, and that the mechanism is strongly associated with activation of an apoptotic pathway.<\/jats:p>","DOI":"10.1159\/000071952","type":"journal-article","created":{"date-parts":[[2003,8,18]],"date-time":"2003-08-18T08:23:26Z","timestamp":1061195006000},"page":"164-171","source":"Crossref","is-referenced-by-count":15,"title":["Postischemic Hyperthermia Induced Caspase-3 Activation in the Newborn Rat Brain after Hypoxia-Ischemia and Exacerbated the Brain Damage"],"prefix":"10.1159","volume":"84","author":[{"given":"Hirotsugu","family":"Fukuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuji","family":"Tomimatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kanagawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junwu","family":"Mu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatomo","family":"Kohzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Shimoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayoshi","family":"Hosono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Kanzaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Murata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,8,15]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1097\/00004647-200009000-00003"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1016\/S0304-3940(01)02178-4"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1038\/34112"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1038\/sj.cdd.4400449"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1046\/j.1471-4159.2000.0750819.x"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1159\/000047087"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1016\/S0304-3940(99)00979-9"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1016\/S0140-6736(96)90008-2"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1097\/00000542-199508000-00013"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1053\/siny.2001.0041"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/71952","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/71952","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:34:22Z","timestamp":1745465662000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000071952"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2003,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000071952","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2003]]}}}