{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:10:23Z","timestamp":1745554223420,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2003,8,5]],"date-time":"2003-08-05T00:00:00Z","timestamp":1060041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,8,5]],"date-time":"2003-08-05T00:00:00Z","timestamp":1060041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Physiol"],"abstract":"<jats:p>The mineralocorticoid receptor mediates the effects of aldosterone. In addition to its influence on fluid and electrolyte, aldosterone plays a role in cardiac hypertrophy, tissue fibrosis, and modulation of vascular reactivity. However, the intracellular signaling mechanisms induced by aldosterone are not fully understood. Aldosterone causes slow transcriptional and rapid non-transcriptional effects. The latter include changes in intracellular calcium, c-Jun N-terminal kinase (JNK) and extracellularly regulated kinase (ERK) phosphorylation. In addition, autocrine loops involving other molecules such as the epidermal growth factor (EGF) receptor are also important in aldosterone-induced cellular mechanisms. This short review covers in vitro and in vivo studies that have investigated the pathophysiological role of aldosterone and the mineralocorticoid receptor in the cardiovascular system.<\/jats:p>","DOI":"10.1159\/000072029","type":"journal-article","created":{"date-parts":[[2003,8,6]],"date-time":"2003-08-06T10:32:03Z","timestamp":1060165923000},"page":"p47-p50","source":"Crossref","is-referenced-by-count":17,"title":["Participation of the Mineralocorticoid Receptor in Cardiac and Vascular Remodeling"],"prefix":"10.1159","volume":"94","author":[{"given":"Anette","family":"Fiebeler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hermann","family":"Haller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,8,5]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199909023411001"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030207"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210\/jc.82.5.1345"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.273.9.4883"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1771"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)03017-X"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.59.1.365"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000025879.29822.24"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200215481"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000053846.71621.93"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000015854.60710.10"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210\/en.2002-220120"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102673599"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1126\/science.289.5476.119"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.2.761"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9150(02)00363-5"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000044937.95080.E9"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000049881.25304.73"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000068086"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2000.00965.x"}],"container-title":["Nephron Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/72029","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/72029","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:35:44Z","timestamp":1745465744000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000072029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,8,5]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2003,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000072029","archive":["Portico"],"relation":{},"ISSN":["1660-2137"],"issn-type":[{"type":"electronic","value":"1660-2137"}],"subject":[],"published":{"date-parts":[[2003,8,5]]}}}