{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T00:38:12Z","timestamp":1772498292829,"version":"3.50.1"},"reference-count":2,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Aims:&lt;\/i&gt; Minimal change disease (MCD) is the most common primary nephrotic syndrome in children. Some suggested that interleukin-8 (IL-8) and tumor necrosis factor-\u03b1 (TNF-\u03b1) are involved in the pathogenesis of MCD. This study was done to see changes of plasma and urinary IL-8, TNF-\u03b1, and their effects on determination of permeability of glomerular basement membrane (BM) contributed by heparan sulfate proteoglycan (HSPG). &lt;i&gt;Methods:&lt;\/i&gt; Study patients consisted of 19 biopsy-proven MCD children aged 2\u201315 years old. Both plasma, urinary IL-8 and TNF-\u03b1 were measured. Employing the Millicell system, IL-8 and TNF-\u03b1 were screened for the permeability factors. We examined whether IL-8 and TNF-\u03b1 regulated BM HSPG gene expression and HS synthesis in the glomerular epithelial cells (GECs). &lt;i&gt;Results:&lt;\/i&gt; Urinary IL-8 during relapse was significantly increased when compared with that of during remission or controls (13,996 \u00b1 2,811 vs. 2,941 \u00b1 373, 5,331 \u00b1 640 ng\/mg\u00b7cr) (p &lt; 0.05). Urinary TNF-\u03b1 during relapse was also significantly increased (364.4 \u00b1 51.2 vs. 155.3 \u00b1 20.8, 36.0 \u00b1 4.5 ng\/mg\u00b7cr) (p &lt; 0.05). Plasma IL-8 during relapse was significantly increased compared to that during remission(1.19 \u00b1 0.62 vs. 0.51 \u00b1 0.42 ng\/ml) (p &lt; 0.05). However, the negative results were obtained in the permeability assay using the Millicell system. No difference was seen in BM HSPG gene expression and HS synthesis in the GECs. &lt;i&gt;Conclusion:&lt;\/i&gt; Therefore, it seems that both IL-8 and TNF-\u03b1 may not play a disease-specific role in the pathogenesis of MCD.<\/jats:p>","DOI":"10.1159\/000072065","type":"journal-article","created":{"date-parts":[[2003,7,11]],"date-time":"2003-07-11T08:22:02Z","timestamp":1057911722000},"page":"260-266","source":"Crossref","is-referenced-by-count":30,"title":["Interleukin-8 and Tumor Necrosis Factor-Alpha Are Increased in Minimal Change Disease but Do Not Alter Albumin Permeability"],"prefix":"10.1159","volume":"23","author":[{"given":"Min Hyun","family":"Cho","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwan Seok","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Ho","family":"Choe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soon Hak","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki Young","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ja Hoon","family":"Koo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheol Woo","family":"Ko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,7,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1006\/abio.1987.9999"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.119.3.559"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/72065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/72065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:35:57Z","timestamp":1745465757000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000072065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":2,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2003,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000072065","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}