{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T04:10:33Z","timestamp":1745554233472,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2003]]},"abstract":"This study determined: (1) whether dopamine (DA) D<sub>2<\/sub>-receptor (R) and D<sub>1<\/sub>-R mRNA levels in the carotid body (CB), petrosal ganglion (PG) and superior cervical ganglion (SCG) are modulated by hypoxia; (2) the role of hypoxia intensity and exposure duration, and (3) whether the pattern of modulation differs between newborn (1-day-old) and adult rabbits. Rabbits were exposed to five F<sub>i<\/sub>O<sub>2<\/sub> conditions: 21% (control); 15%\/6 h; 15%\/24 h; 8%\/6 h and 8%\/24 h. D<sub>2<\/sub>- and D<sub>1<\/sub>-R mRNA expression levels were calculated for each hypoxia condition relative to control using RT-PCR analysis. In the CB of 1-day-old rabbits, D<sub>2<\/sub>- and D<sub>1<\/sub>-R transcript levels increased and decreased after exposure to 15 and 8% O<sub>2<\/sub>, respectively. In the adult CB, D<sub>2<\/sub>- and D<sub>1<\/sub>-R transcript levels decreased independently of hypoxia intensities. Only changes in D<sub>1<\/sub>-R mRNA levels were dependent on exposure time. In the PG, both hypoxia intensities decreased the D<sub>2<\/sub>-R transcript levels in 1-day-old and adult rabbits; but for the D<sub>1<\/sub>-R mRNA levels, hypoxia decreased its level in 1-day-old rabbits and increased it in adults regardless of exposure duration. In the SCG, hypoxia had no determinant effect on the D<sub>2<\/sub>-R mRNA levels either in newborn or adult rabbits while it induced a decrease of D<sub>1<\/sub>-R transcript levels in 1-day-old rabbits and an increase in adult rabbits. It is concluded that hypoxia affects DA D<sub>2<\/sub>- or D<sub>1<\/sub>-R mRNA levels in the chemoreflex pathway in an age-dependent and site-specific manner.<\/jats:p>","DOI":"10.1159\/000072306","type":"journal-article","created":{"date-parts":[[2003,9,26]],"date-time":"2003-09-26T10:26:33Z","timestamp":1064571993000},"page":"222-231","source":"Crossref","is-referenced-by-count":12,"title":["Differential Changes in Dopamine D<sub>2<\/sub>- and D<sub>1<\/sub>-Receptor mRNA Levels Induced by Hypoxia in the Arterial Chemoreflex Pathway Organs in One-Day-Old and Adult Rabbits"],"prefix":"10.1159","volume":"84","author":[{"given":"Aida","family":"Bairam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John L.","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yves","family":"Labelle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edouard W.","family":"Khandjian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,9,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2000.00525.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(00)00131-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(99)00321-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(91)90315-K"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038\/336783a0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00399-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(81)90245-1"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(98)00555-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0034-5687(97)00076-5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)01394-2"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/72306","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/72306","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:39:13Z","timestamp":1745465953000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000072306"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2003,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000072306","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2003]]}}}