{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:15:12Z","timestamp":1762100112358,"version":"3.40.4"},"reference-count":2,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Although the phospholipase activity is considered a potential virulence determinant of the pathogenic &lt;i&gt;Candida&lt;\/i&gt; species, the effect of antimycotics on this attribute is not known. Hence we evaluated the phospholipase activity in 10 isolates each of &lt;i&gt;Candida albicans&lt;\/i&gt; and &lt;i&gt;Candida tropicalis,&lt;\/i&gt; after their exposure to antifungals. &lt;i&gt;Methods:&lt;\/i&gt; The impact of antimycotics on phospholipase activity was also assessed after exposure of the isolates to sub-minimum inhibitory concentrations of nystatin, amphotericin B and fluconazole. &lt;i&gt;Results:&lt;\/i&gt; All &lt;i&gt;Candida&lt;\/i&gt; isolates investigated exhibited phospholipase activity (Pz). In general &lt;i&gt;C.\u00a0albicans&lt;\/i&gt; showed relatively higher P&lt;sub&gt;z&lt;\/sub&gt; activity than &lt;i&gt;C.\u00a0tropicalis,&lt;\/i&gt; and exposure of the isolates to antimycotics led to a significant (p &lt; 0.05) reduction in the phospholipase activity. Nystatin and amphotericin B, but not fluconazole, significantly reduced the phospholipase activity of both &lt;i&gt;Candida&lt;\/i&gt; species. &lt;i&gt;Conclusion:&lt;\/i&gt; These observations, while confirming the higher virulence of &lt;i&gt;C.\u00a0albicans&lt;\/i&gt; relative to &lt;i&gt;C.\u00a0tropicalis,&lt;\/i&gt; demonstrate for the first time the effect of antifungal agents on extracellular phospholipases of these common opportunistic pathogens.<\/jats:p>","DOI":"10.1159\/000072448","type":"journal-article","created":{"date-parts":[[2003,9,26]],"date-time":"2003-09-26T10:26:33Z","timestamp":1064571993000},"page":"243-247","source":"Crossref","is-referenced-by-count":30,"title":["Brief Exposure to Antimycotics Reduces the Extracellular Phospholipase Activity of &lt;i&gt;Candida albicans&lt;\/i&gt; and &lt;i&gt;Candida tropicalis&lt;\/i&gt;"],"prefix":"10.1159","volume":"49","author":[{"given":"S.","family":"Anil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.P.","family":"Samaranayake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2003,9,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.45.1.187"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1601-0825.2002.01818.x"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/72448","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/72448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:40:14Z","timestamp":1745466014000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000072448"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":2,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2003,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000072448","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"type":"print","value":"0009-3157"},{"type":"electronic","value":"1421-9794"}],"subject":[],"published":{"date-parts":[[2003]]}}}