{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:51:04Z","timestamp":1787017864169,"version":"build-2736575974"},"reference-count":4,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T00:00:00Z","timestamp":1041379200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2003]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Chronic eosinophilic pneumonia (CEP) is highly sensitive to systemic corticosteroids, but frequently relapses if the dose is tapered or treatment discontinued. Long-term usage of systemic corticosteroids may cause side effects. Alternative treatments are therefore desired. &lt;i&gt;Objectives:&lt;\/i&gt; We evaluated the response of CEP to monotherapy with inhaled corticosteroids (ICS). &lt;i&gt;Methods:&lt;\/i&gt; Four patients who had CEP without spontaneous resolution were studied. Patients received inhaled beclomethasone dipropionate (BDP) at a dose of 0.8 mg\/day in 1 patient and 1.6 mg\/day in 3 patients for 2 weeks. Treatment was continued if a patient showed improvement in at least 1 of the following indices: radiological findings, symptoms, and blood eosinophilia. &lt;i&gt;Results:&lt;\/i&gt; After the initial 2 weeks of treatment with BDP, the blood eosinophil count increased in 2 patients and decreased in 2. Symptoms worsened in 2 and improved in 2. Infiltrates on chest radiography increased in 3 and showed little change in 1. In the 2 patients with worsening of all 3 outcome indices, oral prednisolone was started; the indices improved. In the remaining 2 patients, BDP alone was continued. One patient had worsening of CEP after 2 months of treatment, and another had relapse of CEP at 3.5 years while receiving 1.6 mg\/day of BDP. All patients thus finally had worsening or relapse of CEP during treatment with BDP. &lt;i&gt;Conclusions:&lt;\/i&gt; ICS may not be effective when given as monotherapy in patients with CEP.<\/jats:p>","DOI":"10.1159\/000072898","type":"journal-article","created":{"date-parts":[[2003,9,26]],"date-time":"2003-09-26T06:26:33Z","timestamp":1064557593000},"page":"362-366","source":"Crossref","is-referenced-by-count":30,"title":["Chronic Eosinophilic Pneumonia: Treatment with Inhaled Corticosteroids"],"prefix":"10.1159","volume":"70","author":[{"given":"Masayoshi","family":"Minakuchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Niimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisako","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoichi","family":"Amitani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Mishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2003,9,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053\/rmed.1999.0587"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.95.08071237"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.97.10020286"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199809000-00001"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/72898","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/72898","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T23:45:02Z","timestamp":1745451902000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000072898"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003]]},"references-count":4,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2003,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000072898","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003]]}}}